UniProt data
UniProt name: TIM21_HUMAN (Q9BVV7)
Gene name: TIMM21; Synonyms=C18orf55, TIM21; ORFNames=HSPC154
Organism: Homo sapiens (Human).
Function: Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. {ECO:0000269|PubMed:23260140}.
Subcellular location: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 108-128, 21 AA, Helical. {ECO:0000255}.
Sequence: 248 AA
CATM prediction
The sequence of TIM21_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 110 120 13 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GRDFTYLIVVLFGISITGGLFYTIFKE | 6.8 | -52.0° | 1.8 | 35.1 | -25.2 |
| Model 2 | GRDFTYLIVVLFGISITGGLFYTIFKE | 7.3 | -46.0° | 2.7 | 46.9 | -0.7 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 119, SER, HA | A, 118, ILE, O | 3.36Å |
| B, 122, GLY, HA1 | A, 119, SER, O | 2.84Å |
| B, 123, GLY, HA2 | A, 122, GLY, O | 3.48Å |
| B, 120, ILE, HA | A, 126, TYR, OH | 3.04Å |
| A, 119, SER, HA | B, 118, ILE, O | 3.36Å |
| A, 122, GLY, HA1 | B, 119, SER, O | 2.84Å |
| A, 123, GLY, HA2 | B, 122, GLY, O | 3.48Å |
| A, 120, ILE, HA | B, 126, TYR, OH | 3.04Å |
