Transmembrane emp24 domain-containing protein 9

UniProt data

UniProt name: TMED9_HUMAN (Q9BVK6)

Gene name: TMED9; Synonyms=GP25L2

Organism: Homo sapiens (Human).

Function: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.

Transmembrane domains:

  1. 203-222, 20 AA, Helical. {ECO:0000255}.

Sequence: 235 AA

10 20 30 40 50 60 MAVELGVLLV RPRPGTGLGR VMRTLLLVLW LATRGSALYF HIGETEKKCF IEEIPDETMV 70 80 90 100 110 120 IGNYRTQLYD KQREEYQPAT PGLGMFVEVK DPEDKVILAR QYGSEGRFTF TSHTPGEHQI 130 140 150 160 170 180 CLHSNSTKFS LFAGGMLRVH LDIQVGEHAN DYAEIAAKDK LSELQLRVRQ LVEQVEQIQK 190 200 210 220 230 EQNYQRWREE RFRQTSESTN QRVLWWSILQ TLILVAIGVW QMRHLKSFFE AKKLV

CATM prediction

The sequence of TMED9_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  200       210       220   
|    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 NQRVLWWSILQTLILVAIGVWQMRHL 7.3 -51.0° 2.4 44.9 -7.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 215, VAL, HA A, 214, LEU, O 3.42Å
B, 218, GLY, HA1 A, 215, VAL, O 3.22Å
A, 215, VAL, HA B, 214, LEU, O 3.42Å
A, 218, GLY, HA1 B, 215, VAL, O 3.22Å