Monoacylglycerol lipase ABHD6 {ECO:0000305}

UniProt data

UniProt name: ABHD6_HUMAN (Q9BV23)

Gene name: ABHD6 {ECO:0000312|HGNC:HGNC:21398}

Organism: Homo sapiens (Human).

Function: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151}.

Subcellular location: Membrane {ECO:0000250|UniProtKB:Q8R2Y0}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion {ECO:0000250|UniProtKB:Q8R2Y0}.

Transmembrane domains:

  1. 9-29, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 337 AA

10 20 30 40 50 60 MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYVHHEDYQF 70 80 90 100 110 120 CYSFRGRPGH KPSILMLHGF SAHKDMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS 130 140 150 160 170 180 IDGQVKRIHQ FVECLKLNKK PFHLVGTSMG GQVAGVYAAY YPSDVSSLCL VCPAGLQYST 190 200 210 220 230 240 DNQFVQRLKE LQGSAAVEKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN 250 260 270 280 290 300 NFYRKLFLEI VSEKSRYSLH QNMDKIKVPT QIIWGKQDQV LDVSGADMLA KSIANCQVEL 310 320 330 LENCGHSVVM ERPRKTAKLI IDFLASVHNT DNNKKLD

CATM prediction

The sequence of ABHD6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      10        20        30 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VNMFVIAGGTLAIAILAFVASFLLWAS 6.8 -55.0° 1.5 45.1 -14.6
Prolines* VNMFVIAGGTLAIPILAFVASFLLWPS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 10, VAL, HA A, 9, PHE, O 3.37Å
B, 13, GLY, HA1 A, 10, VAL, O 2.76Å
B, 14, GLY, HA2 A, 13, GLY, O 3.21Å
A, 10, VAL, HA B, 9, PHE, O 3.37Å
A, 13, GLY, HA1 B, 10, VAL, O 2.76Å
A, 14, GLY, HA2 B, 13, GLY, O 3.21Å