Leucine-rich repeat and fibronectin type-III domain-containing protein 3

UniProt data

UniProt name: LRFN3_HUMAN (Q9BTN0)

Gene name: LRFN3; Synonyms=SALM4; ORFNames=UNQ5865/PRO34192

Organism: Homo sapiens (Human).

Function: Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Transmembrane domains:

  1. 540-560, 21 AA, Helical. {ECO:0000255}.

Sequence: 628 AA

10 20 30 40 50 60 MAILPLLLCL LPLAPASSPP QSATPSPCPR RCRCQTQSLP LSVLCPGAGL LFVPPSLDRR 70 80 90 100 110 120 AAELRLADNF IASVRRRDLA NMTGLLHLSL SRNTIRHVAA GAFADLRALR ALHLDGNRLT 130 140 150 160 170 180 SLGEGQLRGL VNLRHLILSN NQLAALAAGA LDDCAETLED LDLSYNNLEQ LPWEALGRLG 190 200 210 220 230 240 NVNTLGLDHN LLASVPAGAF SRLHKLARLD MTSNRLTTIP PDPLFSRLPL LARPRGSPAS 250 260 270 280 290 300 ALVLAFGGNP LHCNCELVWL RRLAREDDLE ACASPPALGG RYFWAVGEEE FVCEPPVVTH 310 320 330 340 350 360 RSPPLAVPAG RPAALRCRAV GDPEPRVRWV SPQGRLLGNS SRARAFPNGT LELLVTEPGD 370 380 390 400 410 420 GGIFTCIAAN AAGEATAAVE LTVGPPPPPQ LANSTSCDPP RDGDPDALTP PSAASASAKV 430 440 450 460 470 480 ADTGPPTDRG VQVTEHGATA ALVQWPDQRP IPGIRMYQIQ YNSSADDILV YRMIPAESRS 490 500 510 520 530 540 FLLTDLASGR TYDLCVLAVY EDSATGLTAT RPVGCARFST EPALRPCGAP HAPFLGGTMI 550 560 570 580 590 600 IALGGVIVAS VLVFIFVLLM RYKVHGGQPP GKAKIPAPVS SVCSQTNGAL GPTPTPAPPA 610 620 PEPAALRAHT VVQLDCEPWG PGHEPVGP

CATM prediction

The sequence of LRFN3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     540       550       560 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 GTMIIALGGVIVASVLVFIFVLLMRYK 7.2 -44.1° 1.8 44.9 -16.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 542, ALA, HA A, 541, ILE, O 3.41Å
B, 545, GLY, HA1 A, 542, ALA, O 3.19Å
B, 546, VAL, HA A, 545, GLY, O 3.44Å
A, 542, ALA, HA B, 541, ILE, O 3.41Å
A, 545, GLY, HA1 B, 542, ALA, O 3.19Å
A, 546, VAL, HA B, 545, GLY, O 3.44Å