Synaptotagmin-11

UniProt data

UniProt name: SYT11_HUMAN (Q9BT88)

Gene name: SYT11; Synonyms=KIAA0080

Organism: Homo sapiens (Human).

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000269|PubMed:12925569}; Single-pass membrane protein {ECO:0000269|PubMed:12925569}. Cell junction, synapse {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Transmembrane domains:

  1. 16-36, 21 AA, Helical. {ECO:0000255}.

Sequence: 431 AA

10 20 30 40 50 60 MAEITNIRPS FDVSPVVAGL IGASVLVVCV SVTVFVWSCC HQQAEKKQKN PPYKFIHMLK 70 80 90 100 110 120 GISIYPETLS NKKKIIKVRR DKDGPGREGG RRNLLVDAAE AGLLSRDKDP RGPSSGSCID 130 140 150 160 170 180 QLPIKMDYGE ELRSPITSLT PGESKTTSPS SPEEDVMLGS LTFSVDYNFP KKALVVTIQE 190 200 210 220 230 240 AHGLPVMDDQ TQGSDPYIKM TILPDKRHRV KTRVLRKTLD PVFDETFTFY GIPYSQLQDL 250 260 270 280 290 300 VLHFLVLSFD RFSRDDVIGE VMVPLAGVDP STGKVQLTRD IIKRNIQKCI SRGELQVSLS 310 320 330 340 350 360 YQPVAQRMTV VVLKARHLPK MDITGLSGNP YVKVNVYYGR KRIAKKKTHV KKCTLNPIFN 370 380 390 400 410 420 ESFIYDIPTD LLPDISIEFL VIDFDRTTKN EVVGRLILGA HSVTASGAEH WREVCESPRK 430 PVAKWHSLSE Y

CATM prediction

The sequence of SYT11_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         20        30        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VSAVVAGLIGASVLVVCVSVTVFVWSC 7.0 -45.9° 2.7 47.0 -21.8
Model 2 VSAVVAGLIGASVLVVCVSVTVFVWSC 6.8 -55.0° 4.2 37.8 -16.9
Prolines* VSPVVAGLIGASVLVVCVSVTVFVWSC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, GLY, HA1 A, 16, VAL, O 2.89Å
B, 20, LEU, HA A, 19, GLY, O 3.42Å
A, 19, GLY, HA1 B, 16, VAL, O 2.89Å
A, 20, LEU, HA B, 19, GLY, O 3.42Å