Apoptosis-inducing factor 2

UniProt data

UniProt name: AIFM2_HUMAN (Q9BRQ8)

Gene name: AIFM2; Synonyms=AMID, PRG3 {ECO:0000303|PubMed:12135761}

Organism: Homo sapiens (Human).

Function: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:15958387}.

Subcellular location: Cytoplasm. Mitochondrion outer membrane. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.

Transmembrane domains:

  1. 7-27, 21 AA, Helical. {ECO:0000255}.

Sequence: 373 AA

10 20 30 40 50 60 MGSQVSVESG ALHVVIVGGG FGGIAAASQL QALNVPFMLV DMKDSFHHNV AALRASVETG 70 80 90 100 110 120 FAKKTFISYS VTFKDNFRQG LVVGIDLKNQ MVLLQGGEAL PFSHLILATG STGPFPGKFN 130 140 150 160 170 180 EVSSQQAAIQ AYEDMVRQVQ RSRFIVVVGG GSAGVEMAAE IKTEYPEKEV TLIHSQVALA 190 200 210 220 230 240 DKELLPSVRQ EVKEILLRKG VQLLLSERVS NLEELPLNEY REYIKVQTDK GTEVATNLVI 250 260 270 280 290 300 LCTGIKINSS AYRKAFESRL ASSGALRVNE HLQVEGHSNV YAIGDCADVR TPKMAYLAGL 310 320 330 340 350 360 HANIAVANIV NSVKQRPLQA YKPGALTFLL SMGRNDGVGQ ISGFYVGRLM VRLTKSRDLF 370 VSTSWKTMRQ SPP

CATM prediction

The sequence of AIFM2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        3
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 QVSVESGALHVVIVGGGFGGIAAASQL 6.4 -46.9° 3.9 53.0 -24.2
Model 2 QVSVESGALHVVIVGGGFGGIAAASQL 7.3 -51.7° 0.6 48.1 -2.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, GLY, HA1 A, 16, ILE, O 3.34Å
B, 20, GLY, HA2 A, 19, GLY, O 2.36Å
B, 23, GLY, HA1 A, 20, GLY, O 2.65Å
A, 19, GLY, HA1 B, 16, ILE, O 3.34Å
A, 20, GLY, HA2 B, 19, GLY, O 2.36Å
A, 23, GLY, HA1 B, 20, GLY, O 2.65Å