Hephaestin

UniProt data

UniProt name: HEPH_HUMAN (Q9BQS7)

Gene name: HEPH; Synonyms=KIAA0698; ORFNames=UNQ2562/PRO6242

Organism: Homo sapiens (Human).

Function: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1111-1131, 21 AA, Helical. {ECO:0000255}.

Sequence: 1158 AA

10 20 30 40 50 60 MESGHLLWAL LFMQSLWPQL TDGATRVYYL GIRDVQWNYA PKGRNVITNQ PLDSDIVASS 70 80 90 100 110 120 FLKSDKNRIG GTYKKTIYKE YKDDSYTDEV AQPAWLGFLG PVLQAEVGDV ILIHLKNFAT 130 140 150 160 170 180 RPYTIHPHGV FYEKDSEGSL YPDGSSGPLK ADDSVPPGGS HIYNWTIPEG HAPTDADPAC 190 200 210 220 230 240 LTWIYHSHVD APRDIATGLI GPLITCKRGA LDGNSPPQRQ DVDHDFFLLF SVVDENLSWH 250 260 270 280 290 300 LNENIATYCS DPASVDKEDE TFQESNRMHA INGFVFGNLP ELNMCAQKRV AWHLFGMGNE 310 320 330 340 350 360 IDVHTAFFHG QMLTTRGHHT DVANIFPATF VTAEMVPWEP GTWLISCQVN SHFRDGMQAL 370 380 390 400 410 420 YKVKSCSMAP PVDLLTGKVR QYFIEAHEIQ WDYGPMGHDG STGKNLREPG SISDKFFQKS 430 440 450 460 470 480 SSRIGGTYWK VRYEAFQDET FQEKMHLEED RHLGILGPVI RAEVGDTIQV VFYNRASQPF 490 500 510 520 530 540 SMQPHGVFYE KDYEGTVYND GSSYPGLVAK PFEKVTYRWT VPPHAGPTAQ DPACLTWMYF 550 560 570 580 590 600 SAADPIRDTN SGLVGPLLVC RAGALGADGK QKGVDKEFFL LFTVLDENKS WYSNANQAAA 610 620 630 640 650 660 MLDFRLLSED IEGFQDSNRM HAINGFLFSN LPRLDMCKGD TVAWHLLGLG TETDVHGVMF 670 680 690 700 710 720 QGNTVQLQGM RKGAAMLFPH TFVMAIMQPD NLGTFEIYCQ AGSHREAGMR AIYNVSQCPG 730 740 750 760 770 780 HQATPRQRYQ AARIYYIMAE EVEWDYCPDR SWEREWHNQS EKDSYGYIFL SNKDGLLGSR 790 800 810 820 830 840 YKKAVFREYT DGTFRIPRPR TGPEEHLGIL GPLIKGEVGD ILTVVFKNNA SRPYSVHAHG 850 860 870 880 890 900 VLESTTVWPL AAEPGEVVTY QWNIPERSGP GPNDSACVSW IYYSAVDPIK DMYSGLVGPL 910 920 930 940 950 960 AICQKGILEP HGGRSDMDRE FALLFLIFDE NKSWYLEENV ATHGSQDPGS INLQDETFLE 970 980 990 1000 1010 1020 SNKMHAINGK LYANLRGLTM YQGERVAWYM LAMGQDVDLH TIHFHAESFL YRNGENYRAD 1030 1040 1050 1060 1070 1080 VVDLFPGTFE VVEMVASNPG TWLMHCHVTD HVHAGMETLF TVFSRTEHLS PLTVITKETE 1090 1100 1110 1120 1130 1140 KAVPPRDIEE GNVKMLGMQI PIKNVEMLAS VLVAISVTLL LVVLALGGVV WYQHRQRKLR 1150 RNRRSILDDS FKLLSFKQ

CATM prediction

The sequence of HEPH_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    1110      1120      1130 
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LASVLVAISVTLLLVVLALGGVVWYQH 6.9 -54.9° 1.5 44.6 -10.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1127, GLY, HA1 A, 1124, LEU, O 2.99Å
B, 1128, GLY, HA2 A, 1127, GLY, O 3.41Å
A, 1127, GLY, HA1 B, 1124, LEU, O 2.99Å
A, 1128, GLY, HA2 B, 1127, GLY, O 3.41Å