Synaptotagmin-15

UniProt data

UniProt name: SYT15_HUMAN (Q9BQS2)

Gene name: SYT15

Organism: Homo sapiens (Human).

Function: May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. {ECO:0000250}.

Subcellular location: Isoform 4: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 5-29, 25 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 421 AA

10 20 30 40 50 60 MAEQLALVIG GTIGGLLLLL LIGASCCLWR RFCATLTYEE LPGTPAMATT AASSGQRDRP 70 80 90 100 110 120 CQPHARTQLS RPPAVPFVVP PTLQGRDWVP LHSGEWADAP WDPCPASELL PHTSSGGLGD 130 140 150 160 170 180 ACMVGAINPE LYKFPEDKSE TDFPDGCLGR LWFSVEYEQE AERLLVGLIK AQHLQAPSET 190 200 210 220 230 240 CSPLVKLYLL PDERRFLQSK TKRKTSNPQF DEHFIFQVSS KTITQRVLKF SVYHVDRQRK 250 260 270 280 290 300 HQLLGQVLFP LKNETLVGDC RRVIWRDLEA ESLEPPSEFG DLQFCLSYND YLSRLTVVVL 310 320 330 340 350 360 RAKGLRLQED RGIVSVFVKV SLMNHNKFVK CKKTSAVLGS INPVYNETFS FKADATELDT 370 380 390 400 410 420 ASLSLTVVQN MEGDKSQQLG RVVVGPYMYT RGRELEHWDE MLSKPKELVK RWHALCRTTE P

CATM prediction

The sequence of SYT15_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          10        20        30 
   +    |    +    |    +    |  
(Å) (°) (Å) (°)  
AEQLALVIGGTIGGLLLLLLIGASCCLWRRF 6.3 -51.1° 4.4 40.0 -15.0
AEQLALVIGGTIGGLLLLLLIGASCCLWRRF 7.0 -29.3° 2.5 60.4 -9.2
AEQLALVIGGTIGGLLLLLLIGASCCLWRRF 7.2 -53.4° 1.9 45.0 -6.4
AEQLALVIGGTIGGLLLLLLIGASCCLWRRF 7.1 -39.9° 4.5 43.9 -4.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 10, GLY, HA1 A, 7, LEU, O 3.23Å
B, 11, GLY, HA2 A, 10, GLY, O 2.29Å
B, 11, GLY, HA2 A, 11, GLY, O 3.47Å
B, 14, GLY, HA1 A, 11, GLY, O 2.58Å
A, 10, GLY, HA1 B, 7, LEU, O 3.23Å
A, 11, GLY, HA2 B, 10, GLY, O 2.29Å
A, 11, GLY, HA2 B, 11, GLY, O 3.47Å
A, 14, GLY, HA1 B, 11, GLY, O 2.58Å