Selenoprotein S

UniProt data

UniProt name: SELS_HUMAN (Q9BQE4)

Gene name: VIMP; Synonyms=SELS; ORFNames=AD-015, SBBI8

Organism: Homo sapiens (Human).

Function: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250}.

Transmembrane domains:

  1. 28-48, 21 AA, Helical. {ECO:0000255}.

Sequence: 189 AA

10 20 30 40 50 60 MERQEESLSA RPALETEGLR FLHTTVGSLL ATYGWYIVFS CILLYVVFQK LSARLRALRQ 70 80 90 100 110 120 RQLDRAAAAV EPDVVVKRQE ALAAARLKMQ EELNAQVEKH KEKLKQLEEE KRRQKIEMWD 130 140 150 160 170 180 SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK RKSDRKPLRG GGYNPLSGEG GGACSWRPGR RGPSSGGUG

CATM prediction

The sequence of SELS_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       30        40        50
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TVGSLLATYGWYIVFSCILLYVVFQKL 6.8 +38.0° 4.0 77.0 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 31, ALA, HA A, 30, LEU, O 3.40Å
A, 31, ALA, HA B, 30, LEU, O 3.40Å