Regulator of microtubule dynamics protein 3

UniProt data

UniProt name: RMD3_HUMAN (Q96TC7)

Gene name: RMDN3; Synonyms=FAM82A2, FAM82C, PTPIP51

Organism: Homo sapiens (Human).

Function: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.

Subcellular location: Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Transmembrane domains:

  1. 13-35, 23 AA, Helical. {ECO:0000255}.

Sequence: 470 AA

10 20 30 40 50 60 MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS LDYTQTSDPG 70 80 90 100 110 120 RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS LVALRREVEE LRSSLRGLAG 130 140 150 160 170 180 EIVGEVRCHM EENQRVARRR RFPFVRERSD STGSSSVYFT ASSGATFTDA ESEGGYTTAN 190 200 210 220 230 240 AESDNERDSD KESEDGEDEV SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP 250 260 270 280 290 300 LLQQADELHR GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY 310 320 330 340 350 360 ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE HVDKAIALQP 370 380 390 400 410 420 ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE DALQSFLKAE ELQPGFSKAG 430 440 450 460 RVYISKCYRE LGKNSEARWW MKLALELPDV TKEDLAIQKD LEELEVILRD

CATM prediction

The sequence of RMD3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  10        20        30       
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 ARAGLGLLLGTAAGLGFLCLLYSQRWKRT 7.2 -37.0° 2.3 36.1 -25.5
Model 2 ARAGLGLLLGTAAGLGFLCLLYSQRWKRT 6.8 -28.0° 1.5 48.0 -15.6
Model 3 ARAGLGLLLGTAAGLGFLCLLYSQRWKRT 6.8 -47.0° 4.8 55.7 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 16, LEU, HA A, 15, GLY, O 2.54Å
B, 19, GLY, HA1 A, 16, LEU, O 3.41Å
A, 16, LEU, HA B, 15, GLY, O 2.54Å
A, 19, GLY, HA1 B, 16, LEU, O 3.41Å