Protein ABHD1 {ECO:0000305}

UniProt data

UniProt name: ABHD1_HUMAN (Q96SE0)

Gene name: ABHD1 {ECO:0000312|HGNC:HGNC:17553}; Synonyms=LABH1

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 17-37, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 405 AA

10 20 30 40 50 60 MLSSFLSPQN GTWADTFSLL LALAVALYLG YYWACVLQRP RLVAGPQFLA FLEPHCSITT 70 80 90 100 110 120 ETFYPTLWCF EGRLQSIFQV LLQSQPLVLY QSDILQTPDG GQLLLDWAKQ PDSSQDPDPT 130 140 150 160 170 180 TQPIVLLLPG ITGSSQDTYV LHLVNQALRD GYQAVVFNNR GCRGEELRTH RAFCASNTED 190 200 210 220 230 240 LETVVNHIKH RYPQAPLLAV GISFGGILVL NHLAQARQAA GLVAALTLSA CWDSFETTRS 250 260 270 280 290 300 LETPLNSLLF NQPLTAGLCQ LVERNRKVIE KVVDIDFVLQ ARTIRQFDER YTSVAFGYQD 310 320 330 340 350 360 CVTYYKAASP RTKIDAIRIP VLYLSAADDP FSPVCALPIQ AAQHSPYVAL LITARGGHIG 370 380 390 400 FLEGLLPWQH WYMSRLLHQY AKAIFQDPEG LPDLRALLPS EDRNS

CATM prediction

The sequence of ABHD1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        20        30        4
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 ADTFSLLLALAVALYLGYYWACVLQRA 6.9 -46.0° 2.7 47.1 -31.6
Prolines* ADTFSLLLALAVALYLGYYWACVLQRP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 27, LEU, HA A, 26, ALA, O 2.92Å
B, 30, GLY, HA1 A, 27, LEU, O 2.89Å
B, 31, TYR, HA A, 30, GLY, O 3.49Å
A, 27, LEU, HA B, 26, ALA, O 2.92Å
A, 30, GLY, HA1 B, 27, LEU, O 2.89Å
A, 31, TYR, HA B, 30, GLY, O 3.49Å