Sialic acid-binding Ig-like lectin 11

UniProt data

UniProt name: SIG11_HUMAN (Q96RL6)

Gene name: SIGLEC11; ORFNames=UNQ9222/PRO28718

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 562-584, 23 AA, Helical. {ECO:0000255}.

Sequence: 698 AA

10 20 30 40 50 60 MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV IVSCNLSYPR 70 80 90 100 110 120 DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR DRFQLTGDPG KGSCSLVIRD 130 140 150 160 170 180 AQREDEAWYF FRVERGSRVR HSFLSNAFFL KVTALTKKPD VYIPETLEPG QPVTVICVFN 190 200 210 220 230 240 WAFKKCPAPS FSWTGAALSP RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ 250 260 270 280 290 300 RTVRLRVAYA PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV 310 320 330 340 350 360 LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS VQYPPENLRV 370 380 390 400 410 420 MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR LSWTRWGQTV GPSQPSDPGV 430 440 450 460 470 480 LELPPIQMEH EGEFTCHAQH PLGSQHVSLS LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS 490 500 510 520 530 540 PAPSLRWWLG EELLEGNSSQ GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA 550 560 570 580 590 600 QSGSVFQLLP GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD 610 620 630 640 650 660 VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ GLRLWEPADQ 670 680 690 EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK

CATM prediction

The sequence of SIG11_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   560       570       580     
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 LGLGAALGAGVAALLAFCSCLVVFRVKIC 6.7 -43.0° 3.0 35.3 -20.8
Model 2 LGLGAALGAGVAALLAFCSCLVVFRVKIC 7.1 -39.8° 2.7 34.1 -13.5
Model 3 LGLGAALGAGVAALLAFCSCLVVFRVKIC 7.2 -37.0° 2.2 36.0 -11.4
Model 4 LGLGAALGAGVAALLAFCSCLVVFRVKIC 6.5 -38.9° 6.0 44.8 -4.2
Model 5 LGLGAALGAGVAALLAFCSCLVVFRVKIC 7.3 -27.0° 6.0 58.0 -1.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 563, ALA, HA A, 562, GLY, O 2.85Å
B, 566, GLY, HA1 A, 563, ALA, O 2.66Å
B, 567, ALA, HA A, 566, GLY, O 3.04Å
A, 563, ALA, HA B, 562, GLY, O 2.85Å
A, 566, GLY, HA1 B, 563, ALA, O 2.66Å
A, 567, ALA, HA B, 566, GLY, O 3.04Å