Fc receptor-like protein 5

UniProt data

UniProt name: FCRL5_HUMAN (Q96RD9)

Gene name: FCRL5; Synonyms=FCRH5, IRTA2; ORFNames=UNQ503/PRO820

Organism: Homo sapiens (Human).

Function: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. {ECO:0000269|PubMed:11453668}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.

Transmembrane domains:

  1. 852-872, 21 AA, Helical. {ECO:0000255}.

Sequence: 977 AA

10 20 30 40 50 60 MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR 70 80 90 100 110 120 YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV 130 140 150 160 170 180 LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT 190 200 210 220 230 240 VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS 250 260 270 280 290 300 LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE 310 320 330 340 350 360 GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG 370 380 390 400 410 420 LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA 430 440 450 460 470 480 LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA 490 500 510 520 530 540 EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY 550 560 570 580 590 600 CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF 610 620 630 640 650 660 YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI 670 680 690 700 710 720 LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE 730 740 750 760 770 780 HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS RPVLTLRAPG THAAVGDLLE LHCEALRGSP 790 800 810 820 830 840 LILYRFFHED VTLGNRSSPS GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL 850 860 870 880 890 900 TANRSGPFAT GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH 910 920 930 940 950 960 NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS PIIYSEVKVA 970 STPVSGSLFL ASSAPHR

CATM prediction

The sequence of FCRL5_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   850       860       870   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 ATGVAGGLLSIAGLAAGALLLYCWLSR 7.0 -48.7° 2.8 32.1 -1.1
Model 2 ATGVAGGLLSIAGLAAGALLLYCWLSR 6.8 +39.0° 4.7 69.0 -1.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 858, SER, HA A, 857, LEU, O 3.32Å
B, 861, GLY, HA1 A, 858, SER, O 3.00Å
A, 858, SER, HA B, 857, LEU, O 3.32Å
A, 861, GLY, HA1 B, 858, SER, O 3.00Å