SLIT and NTRK-like protein 1

UniProt data

UniProt name: SLIK1_HUMAN (Q96PX8)

Gene name: SLITRK1; Synonyms=KIAA1910, LRRC12; ORFNames=UNQ233/PRO266

Organism: Homo sapiens (Human).

Function: Enhances neuronal dendrite outgrowth. {ECO:0000269|PubMed:16224024}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 623-643, 21 AA, Helical. {ECO:0000255}.

Sequence: 696 AA

10 20 30 40 50 60 MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL QRFTAPTSQF 70 80 90 100 110 120 YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG AFLGLQLVKR LHINNNKIKS 130 140 150 160 170 180 FRKQTFLGLD DLEYLQADFN LLRDIDPGAF QDLNKLEVLI LNDNLISTLP ANVFQYVPIT 190 200 210 220 230 240 HLDLRGNRLK TLPYEEVLEQ IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV 250 260 270 280 290 300 CEAPTRLQGK DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQEDHAT 310 320 330 340 350 360 PGSAPNGGTK IPGNWQIKIR PTAAIATGSS RNKPLANSLP CPGGCSCDHI PGSGLKMNCN 370 380 390 400 410 420 NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN LILLDLGNNN IATVENNTFK 430 440 450 460 470 480 NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE YLNVEYNAIQ LILPGTFNAM PKLRILILNN 490 500 510 520 530 540 NLLRSLPVDV FAGVSLSKLS LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF 550 560 570 580 590 600 KQWAERLGSE VLMSDLKCET PVNFFRKDFM LLSNDEICPQ LYARISPTLT SHSKNSTGLA 610 620 630 640 650 660 ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK RRDANSSASE 670 680 690 INSLQTVCDS SYWHNGPYNA DGAHRVYDCG SHSLSD

CATM prediction

The sequence of SLIK1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  620       630       640    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LVAGLLLVFVTSAFTVVGMLVFILRNR 7.4 -54.0° 3.6 35.1 -9.4
Prolines* LVPGLLLVFVTSAFTVVGMLVFILRNR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 634, THR, HA A, 633, PHE, O 3.50Å
B, 637, GLY, HA1 A, 634, THR, O 3.47Å
A, 634, THR, HA B, 633, PHE, O 3.50Å
A, 637, GLY, HA1 B, 634, THR, O 3.47Å