Sialic acid-binding Ig-like lectin 12

UniProt data

UniProt name: SIG12_HUMAN (Q96PQ1)

Gene name: SIGLEC12; Synonyms=SIGLECL1, SLG; ORFNames=UNQ9215/PRO34042

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 482-502, 21 AA, Helical. {ECO:0000255}.

Sequence: 595 AA

10 20 30 40 50 60 MLLLLLLLPP LLCGRVGAKE QKDYLLTMQK SVTVQEGLCV SVLCSFSYPQ NGWTASDPVH 70 80 90 100 110 120 GYWFRAGDHV SRNIPVATNN PARAVQEETR DRFHLLGDPQ NKDCTLSIRD TRESDAGTYV 130 140 150 160 170 180 FCVERGNMKW NYKYDQLSVN VTASQDLLSR YRLEVPESVT VQEGLCVSVP CSVLYPHYNW 190 200 210 220 230 240 TASSPVYGSW FKEGADIPWD IPVATNTPSG KVQEDTHGRF LLLGDPQTNN CSLSIRDARK 250 260 270 280 290 300 GDSGKYYFQV ERGSRKWNYI YDKLSVHVTA LTHMPTFSIP GTLESGHPRN LTCSVPWACE 310 320 330 340 350 360 QGTPPTITWM GASVSSLDPT ITRSSMLSLI PQPQDHGTSL TCQVTLPGAG VTMTRAVRLN 370 380 390 400 410 420 ISYPPQNLTM TVFQGDGTAS TTLRNGSALS VLEGQSLHLV CAVDSNPPAR LSWTWGSLTL 430 440 450 460 470 480 SPSQSSNLGV LELPRVHVKD EGEFTCRAQN PLGSQHISLS LSLQNEYTGK MRPISGVTLG 490 500 510 520 530 540 AFGGAGATAL VFLYFCIIFV VVRSCRKKSA RPAVGVGDTG MEDANAVRGS ASQGPLIESP 550 560 570 580 590 ADDSPPHHAP PALATPSPEE GEIQYASLSF HKARPQYPQE QEAIGYEYSE INIPK

CATM prediction

The sequence of SIG12_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   480       490       500   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LGAFGGAGATALVFLYFCIIFVVVRSC 7.3 -43.0° 3.0 35.0 -18.2
Model 2 LGAFGGAGATALVFLYFCIIFVVVRSC 7.1 -43.0° 0.0 34.0 -10.1
Model 3 LGAFGGAGATALVFLYFCIIFVVVRSC 6.6 -47.0° 6.0 45.0 -7.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 485, ALA, HA A, 488, THR, OG1 2.66Å
A, 485, ALA, HA B, 488, THR, OG1 2.66Å