Fc receptor-like protein 4

UniProt data

UniProt name: FCRL4_HUMAN (Q96PJ5)

Gene name: FCRL4; Synonyms=FCRH4, IFGP2, IRTA1

Organism: Homo sapiens (Human).

Function: May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. {ECO:0000269|PubMed:14597715}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.

Transmembrane domains:

  1. 388-408, 21 AA, Helical. {ECO:0000255}.

Sequence: 515 AA

10 20 30 40 50 60 MLLWASLLAF APVCGQSAAA HKPVISVHPP WTTFFKGERV TLTCNGFQFY ATEKTTWYHR 70 80 90 100 110 120 HYWGEKLTLT PGNTLEVRES GLYRCQARGS PRSNPVRLLF SSDSLILQAP YSVFEGDTLV 130 140 150 160 170 180 LRCHRRRKEK LTAVKYTWNG NILSISNKSW DLLIPQASSN NNGNYRCIGY GDENDVFRSN 190 200 210 220 230 240 FKIIKIQELF PHPELKATDS QPTEGNSVNL SCETQLPPER SDTPLHFNFF RDGEVILSDW 250 260 270 280 290 300 STYPELQLPT VWRENSGSYW CGAETVRGNI HKHSPSLQIH VQRIPVSGVL LETQPSGGQA 310 320 330 340 350 360 VEGEMLVLVC SVAEGTGDTT FSWHREDMQE SLGRKTQRSL RAELELPAIR QSHAGGYYCT 370 380 390 400 410 420 ADNSYGPVQS MVLNVTVRET PGNRDGLVAA GATGGLLSAL LLAVALLFHC WRRRKSGVGF 430 440 450 460 470 480 LGDETRLPPA PGPGESSHSI CPAQVELQSL YVDVHPKKGD LVYSEIQTTQ LGEEEEANTS 490 500 510 RTLLEDKDVS VVYSEVKTQH PDNSAGKISS KDEES

CATM prediction

The sequence of FCRL4_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       390       400       41
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 DGLVAAGATGGLLSALLLAVALLFHCW 6.6 -41.1° 5.6 44.7 -23.7
Model 2 DGLVAAGATGGLLSALLLAVALLFHCW 6.4 -53.0° 3.2 33.9 -16.8
Model 3 DGLVAAGATGGLLSALLLAVALLFHCW 6.4 -53.4° 5.2 58.1 -4.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 391, GLY, HA1 A, 388, VAL, O 2.83Å
B, 392, ALA, HA A, 391, GLY, O 2.42Å
B, 395, GLY, HA1 A, 392, ALA, O 3.00Å
A, 391, GLY, HA1 B, 388, VAL, O 2.83Å
A, 392, ALA, HA B, 391, GLY, O 2.42Å
A, 395, GLY, HA1 B, 392, ALA, O 3.00Å