Opalin

UniProt data

UniProt name: OPALI_HUMAN (Q96PE5)

Gene name: OPALIN; Synonyms=HTMP10, TMEM10

Organism: Homo sapiens (Human).

Function:

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.

Transmembrane domains:

  1. 30-50, 21 AA, Helical. {ECO:0000255}.

Sequence: 141 AA

10 20 30 40 50 60 MSFSLNFTLP ANTTSSPVTG GKETDCGPSL GLAAGIPLLV ATALLVALLF TLIHRRRSSI 70 80 90 100 110 120 EAMEESDRPC EISEIDDNPK ISENPRRSPT HEKNTMGAQE AHIYVKTVAG SEEPVHDRYR 130 140 PTIEMERRRG LWWLVPRLSL E

CATM prediction

The sequence of OPALI_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     30        40        50  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 GASLGLAAGIALLVATALLVALLFTLI 6.6 -31.0° 4.0 51.0 -19.9
Model 2 GASLGLAAGIALLVATALLVALLFTLI 6.3 -45.0° 2.7 61.0 -12.1
Model 3 GASLGLAAGIALLVATALLVALLFTLI 6.8 -52.0° 5.2 40.0 -1.8
Prolines* GPSLGLAAGIPLLVATALLVALLFTLI          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 32, LEU, HA A, 31, GLY, O 3.33Å
A, 32, LEU, HA B, 31, GLY, O 3.33Å