Nectin-4

UniProt data

UniProt name: NECT4_HUMAN (Q96NY8)

Gene name: NECTIN4 {ECO:0000312|HGNC:HGNC:19688}

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for measles virus. {ECO:0000269|PubMed:22048310, ECO:0000269|PubMed:23202587}.

Subcellular location: Processed poliovirus receptor-related protein 4: Secreted {ECO:0000269|PubMed:15784625}. Note=The secreted form is found in breast tumor patients (PubMed:15784625).

Transmembrane domains:

  1. 350-370, 21 AA, Helical. {ECO:0000255}.

Sequence: 510 AA

10 20 30 40 50 60 MPLSLGAEMW GPEAWLLLLL LLASFTGRCP AGELETSDVV TVVLGQDAKL PCFYRGDSGE 70 80 90 100 110 120 QVGQVAWARV DAGEGAQELA LLHSKYGLHV SPAYEGRVEQ PPPPRNPLDG SVLLRNAVQA 130 140 150 160 170 180 DEGEYECRVS TFPAGSFQAR LRLRVLVPPL PSLNPGPALE EGQGLTLAAS CTAEGSPAPS 190 200 210 220 230 240 VTWDTEVKGT TSSRSFKHSR SAAVTSEFHL VPSRSMNGQP LTCVVSHPGL LQDQRITHIL 250 260 270 280 290 300 HVSFLAEASV RGLEDQNLWH IGREGAMLKC LSEGQPPPSY NWTRLDGPLP SGVRVDGDTL 310 320 330 340 350 360 GFPPLTTEHS GIYVCHVSNE FSSRDSQVTV DVLDPQEDSG KQVDLVSASV VVVGVIAALL 370 380 390 400 410 420 FCLLVVVVVL MSRYHRRKAQ QMTQKYEEEL TLTRENSIRR LHSHHTDPRS QPEESVGLRA 430 440 450 460 470 480 EGHPDSLKDN SSCSVMSEEP EGRSYSTLTT VREIETQTEL LSPGSGRAEE EEDQDEGIKQ 490 500 AMNHFVQENG TLRAKPTGNG IYINGRGHLV

CATM prediction

The sequence of NECT4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     350       360       370 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SASVVVVGVIAALLFCLLVVVVVLMSR 7.2 -54.9° 0.9 50.0 -11.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 354, GLY, HA1 A, 351, VAL, O 3.39Å
B, 355, VAL, HA A, 354, GLY, O 3.43Å
A, 354, GLY, HA1 B, 351, VAL, O 3.39Å
A, 355, VAL, HA B, 354, GLY, O 3.43Å