Leucine-rich repeat and fibronectin type-III domain-containing protein 5

UniProt data

UniProt name: LRFN5_HUMAN (Q96NI6)

Gene name: LRFN5; Synonyms=C14orf146, SALM5

Organism: Homo sapiens (Human).

Function: Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. {ECO:0000269|PubMed:18227064, ECO:0000269|PubMed:18585462}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 530-550, 21 AA, Helical. {ECO:0000255}.

Sequence: 719 AA

10 20 30 40 50 60 MEKILFYLFL IGIAVKAQIC PKRCVCQILS PNLATLCAKK GLLFVPPNID RRTVELRLAD 70 80 90 100 110 120 NFVTNIKRKD FANMTSLVDL TLSRNTISFI TPHAFADLRN LRALHLNSNR LTKITNDMFS 130 140 150 160 170 180 GLSNLHHLIL NNNQLTLISS TAFDDVFALE ELDLSYNNLE TIPWDAVEKM VSLHTLSLDH 190 200 210 220 230 240 NMIDNIPKGT FSHLHKMTRL DVTSNKLQKL PPDPLFQRAQ VLATSGIISP STFALSFGGN 250 260 270 280 290 300 PLHCNCELLW LRRLSREDDL ETCASPPLLT GRYFWSIPEE EFLCEPPLIT RHTHEMRVLE 310 320 330 340 350 360 GQRATLRCKA RGDPEPAIHW ISPEGKLISN ATRSLVYDNG TLDILITTVK DTGAFTCIAS 370 380 390 400 410 420 NPAGEATQIV DLHIIKLPHL LNSTNHIHEP DPGSSDISTS TKSGSNTSSS NGDTKLSQDK 430 440 450 460 470 480 IVVAEATSST ALLKFNFQRN IPGIRMFQIQ YNGTYDDTLV YRMIPPTSKT FLVNNLAAGT 490 500 510 520 530 540 MYDLCVLAIY DDGITSLTAT RVVGCIQFTT EQDYVRCHFM QSQFLGGTMI IIIGGIIVAS 550 560 570 580 590 600 VLVFIIILMI RYKVCNNNGQ HKVTKVSNVY SQTNGAQIQG CSVTLPQSVS KQAVGHEENA 610 620 630 640 650 660 QCCKATSDNV IQSSETCSSQ DSSTTTSALP PSWTSSTSVS QKQKRKTGTK PSTEPQNEAV 670 680 690 700 710 TNVESQNTNR NNSTALQLAS RPPDSVTEGP TSKRAHIKPN ALLTNVDQIV QETQRLELI

CATM prediction

The sequence of LRFN5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     530       540       550 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 GTMIIIIGGIIVASVLVFIIILMIRYK 7.2 -54.8° 0.9 50.4 -15.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 535, GLY, HA1 A, 532, ILE, O 3.38Å
B, 536, ILE, HA A, 535, GLY, O 3.43Å
A, 535, GLY, HA1 B, 532, ILE, O 3.38Å
A, 536, ILE, HA B, 535, GLY, O 3.43Å