Heparan-sulfate 6-O-sulfotransferase 2

UniProt data

UniProt name: H6ST2_HUMAN (Q96MM7)

Gene name: HS6ST2; ORFNames=PSEC0092

Organism: Homo sapiens (Human).

Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 5-27, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 605 AA

10 20 30 40 50 60 MALPACAVRE FEPPRQPERG APVRTTCPRR HSRVEAELAA SRPGSVAASV RAGPPRGVSH 70 80 90 100 110 120 GFHTRPLLDK PRKASSSLAG AACAPLFALL SRGRRRRMHV LRRRWDLGSL CRALLTRGLA 130 140 150 160 170 180 ALGHSLKHVL GAIFSKIFGP MASVGNMDEK SNKLLLALVM LFLFAVIVLQ YVCPGTECQL 190 200 210 220 230 240 LRLQAFSSPV PDPYRSEDES SARFVPRYNF TRGDLLRKVD FDIKGDDLIV FLHIQKTGGT 250 260 270 280 290 300 TFGRHLVRNI QLEQPCECRV GQKKCTCHRP GKRETWLFSR FSTGWSCGLH ADWTELTSCV 310 320 330 340 350 360 PSVVDGKRDA RLRPSRNFHY ITILRDPVSR YLSEWRHVQR GATWKASLHV CDGRPPTSEE 370 380 390 400 410 420 LPSCYTGDDW SGCPLKEFMD CPYNLANNRQ VRMLSDLTLV GCYNLSVMPE KQRNKVLLES 430 440 450 460 470 480 AKSNLKHMAF FGLTEFQRKT QYLFEKTFNM NFISPFTQYN TTRASSVEIN EEIQKRIEGL 490 500 510 520 530 540 NFLDMELYSY AKDLFLQRYQ FMRQKEHQEA RRKRQEQRKF LKGRLLQTHF QSQGQGQSQN 550 560 570 580 590 600 PNQNQSQNPN PNANQNLTQN LMQNLTQSLS QKENRESPKQ NSGKEQNDNT SNGTNDYIGS VEKWR

CATM prediction

The sequence of H6ST2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          10        20        3
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 ALAACAVREFEAARQAERGAAVRTTCARR 7.0 -47.1° 2.2 44.9 -0.6
Prolines* ALPACAVREFEPPRQPERGAPVRTTCPRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 17, ALA, HA A, 16, GLN, O 3.13Å
B, 20, GLY, HA1 A, 17, ALA, O 2.96Å
B, 24, ARG, HE A, 25, THR, OG1 1.83Å
A, 17, ALA, HA B, 16, GLN, O 3.13Å
A, 20, GLY, HA1 B, 17, ALA, O 2.96Å
A, 24, ARG, HE B, 25, THR, OG1 1.83Å