Regulator of microtubule dynamics protein 2

UniProt data

UniProt name: RMD2_HUMAN (Q96LZ7)

Gene name: RMDN2; Synonyms=FAM82A, FAM82A1

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.

Transmembrane domains:

  1. 9-28, 20 AA, Helical. {ECO:0000255}.

Sequence: 410 AA

10 20 30 40 50 60 MPYSTNKELI LGIMVGTAGI SLLLLWYHKV RKPGIAMKLP EFLSLGNTFN SITLQDEIHD 70 80 90 100 110 120 DQGTTVIFQE RQLQILEKLN ELLTNMEELK EEIRFLKEAI PKLEEYIQDE LGGKITVHKI 130 140 150 160 170 180 SPQHRARKRR LPTIQSSATS NSSEEAESEG GYITANTDTE EQSFPVPKAF NTRVEELNLD 190 200 210 220 230 240 VLLQKVDHLR MSESGKSESF ELLRDHKEKF RDEIEFMWRF ARAYGDMYEL STNTQEKKHY 250 260 270 280 290 300 ANIGKTLSER AINRAPMNGH CHLWYAVLCG YVSEFEGLQN KINYGHLFKE HLDIAIKLLP 310 320 330 340 350 360 EEPFLYYLKG RYCYTVSKLS WIEKKMAATL FGKIPSSTVQ EALHNFLKAE ELCPGYSNPN 370 380 390 400 YMYLAKCYTD LEENQNALKF CNLALLLPTV TKEDKEAQKE MQKIMTSLKR

CATM prediction

The sequence of RMD2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      10        20        30
    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 NKELILGIMVGTAGISLLLLWYHKVR 6.9 -25.0° 4.8 51.0 -33.6
Model 2 NKELILGIMVGTAGISLLLLWYHKVR 7.1 -46.8° 1.3 45.2 -17.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 12, GLY, HA1 A, 9, LEU, O 3.43Å
B, 24, LEU, HA A, 27, TYR, OH 2.79Å
A, 12, GLY, HA1 B, 9, LEU, O 3.43Å