Sialic acid-binding Ig-like lectin 10

UniProt data

UniProt name: SIG10_HUMAN (Q96LC7)

Gene name: SIGLEC10; Synonyms=SLG2; ORFNames=UNQ477/PRO940

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Subcellular location: Isoform 5: Secreted.

Transmembrane domains:

  1. 551-571, 21 AA, Helical. {ECO:0000255}.

Sequence: 697 AA

10 20 30 40 50 60 MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW 70 80 90 100 110 120 FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV 130 140 150 160 170 180 ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW 190 200 210 220 230 240 TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD 250 260 270 280 290 300 LVISISRDNT PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP 310 320 330 340 350 360 WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM VSQANRTVLE 370 380 390 400 410 420 NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE 430 440 450 460 470 480 GEFTCHARHP LGSQHVSLSL SVHYSPKLLG PSCSWEAEGL HCSCSSQASP APSLRWWLGE 490 500 510 520 530 540 ELLEGNSSQD SFEVTPSSAG PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK 550 560 570 580 590 600 KGLISTAFSN GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV 610 620 630 640 650 660 VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK SSTQAPESQE 670 680 690 SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ

CATM prediction

The sequence of SIG10_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    550       560       570  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 FSNGAFLGIGITALLFLCLALIIMKIL 6.9 -42.8° 5.6 33.9 -20.7
Model 2 FSNGAFLGIGITALLFLCLALIIMKIL 6.8 -55.3° 4.9 52.8 -2.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 552, ALA, HA A, 551, GLY, O 2.70Å
B, 555, GLY, HA1 A, 552, ALA, O 3.02Å
B, 556, ILE, HA A, 559, THR, OG1 2.80Å
A, 552, ALA, HA B, 551, GLY, O 2.70Å
A, 555, GLY, HA1 B, 552, ALA, O 3.02Å
A, 556, ILE, HA B, 559, THR, OG1 2.80Å