Fc receptor-like protein 1

UniProt data

UniProt name: FCRL1_HUMAN (Q96LA6)

Gene name: FCRL1; Synonyms=FCRH1, IFGP1, IRTA5

Organism: Homo sapiens (Human).

Function: May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269|PubMed:15479727}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.

Transmembrane domains:

  1. 308-328, 21 AA, Helical. {ECO:0000255}.

Sequence: 429 AA

10 20 30 40 50 60 MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA 70 80 90 100 110 120 LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP 130 140 150 160 170 180 GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ 190 200 210 220 230 240 YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY 250 260 270 280 290 300 WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA 310 320 330 340 350 360 RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP 370 380 390 400 410 420 TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAAETLG THMEDKVSLD IYSRLRKANI TDVDYEDAM

CATM prediction

The sequence of FCRL1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       310       320       33
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LTSGVIEGLLSTLGAATVALLFCYGLK 6.5 -51.1° 3.8 55.0 -25.0
Prolines* LTSGVIEGLLSTLGPATVALLFCYGLK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 309, VAL, HA A, 308, GLY, O 2.52Å
B, 312, GLY, HA1 A, 309, VAL, O 2.74Å
B, 313, LEU, HA A, 316, THR, OG1 2.76Å
A, 309, VAL, HA B, 308, GLY, O 2.52Å
A, 312, GLY, HA1 B, 309, VAL, O 2.74Å
A, 313, LEU, HA B, 316, THR, OG1 2.76Å