Fc receptor-like protein 2

UniProt data

UniProt name: FCRL2_HUMAN (Q96LA5)

Gene name: FCRL2; Synonyms=FCRH2, IFGP4, IRTA4, SPAP1

Organism: Homo sapiens (Human).

Function: May have an regulatory role in normal and neoplastic B cell development. {ECO:0000269|PubMed:11493702}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.

Transmembrane domains:

  1. 402-422, 21 AA, Helical. {ECO:0000255}.

Sequence: 508 AA

10 20 30 40 50 60 MLLWSLLVIF DAVTEQADSL TLVAPSSVFE GDSIVLKCQG EQNWKIQKMA YHKDNKELSV 70 80 90 100 110 120 FKKFSDFLIQ SAVLSDSGNY FCSTKGQLFL WDKTSNIVKI KVQELFQRPV LTASSFQPIE 130 140 150 160 170 180 GGPVSLKCET RLSPQRLDVQ LQFCFFRENQ VLGSGWSSSP ELQISAVWSE DTGSYWCKAE 190 200 210 220 230 240 TVTHRIRKQS LQSQIHVQRI PISNVSLEIR APGGQVTEGQ KLILLCSVAG GTGNVTFSWY 250 260 270 280 290 300 REATGTSMGK KTQRSLSAEL EIPAVKESDA GKYYCRADNG HVPIQSKVVN IPVRIPVSRP 310 320 330 340 350 360 VLTLRSPGAQ AAVGDLLELH CEALRGSPPI LYQFYHEDVT LGNSSAPSGG GASFNLSLTA 370 380 390 400 410 420 EHSGNYSCEA NNGLGAQCSE AVPVSISGPD GYRRDLMTAG VLWGLFGVLG FTGVALLLYA 430 440 450 460 470 480 LFHKISGESS ATNEPRGASR PNPQEFTYSS PTPDMEELQP VYVNVGSVDV DVVYSQVWSM 490 500 QQPESSANIR TLLENKDSQV IYSSVKKS

CATM prediction

The sequence of FCRL2_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   400       410       420   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 AGVLWGLFGVLGFTGVALLLYALFHKI 7.1 +52.0° 1.8 1.1 -29.9
Model 2 AGVLWGLFGVLGFTGVALLLYALFHKI 6.9 -55.0° 4.2 38.0 -18.0
Model 3 AGVLWGLFGVLGFTGVALLLYALFHKI 7.1 +52.0° 1.8 1.0 -14.0
Model 4 AGVLWGLFGVLGFTGVALLLYALFHKI 6.6 +38.0° 2.9 92.0 -6.6
Model 5 AGVLWGLFGVLGFTGVALLLYALFHKI 7.4 -54.0° 3.6 49.0 -5.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 410, GLY, HA1 A, 406, PHE, O 3.40Å
B, 410, GLY, HA2 A, 409, LEU, O 3.38Å
A, 410, GLY, HA1 B, 406, PHE, O 3.40Å
A, 410, GLY, HA2 B, 409, LEU, O 3.38Å