Small integral membrane protein 8

UniProt data

UniProt name: SMIM8_HUMAN (Q96KF7)

Gene name: SMIM8; Synonyms=C6orf162; ORFNames=DC18

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 48-70, 23 AA, Helical. {ECO:0000255}.

Sequence: 97 AA

10 20 30 40 50 60 MSSAPEPPTF KKEPPKEKEF QSPGLRGVRT TTLFRAVNPE LFIKPNKPVM AFGLVTLSLC 70 80 90 VAYIGYLHAI QENKKDLYEA IDSEGHSYMR RKTSKWD

CATM prediction

The sequence of SMIM8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       50        60        70  
+    |    +    |    +    |   
(Å) (°) (Å) (°)  
ANKAVMAFGLVTLSLCVAYIGYLHAIQEN 7.3 -43.9° 1.8 45.2 -16.2
PNKPVMAFGLVTLSLCVAYIGYLHAIQEN          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 62, ALA, HA A, 61, VAL, O 3.46Å
B, 65, GLY, HA1 A, 62, ALA, O 3.22Å
B, 66, TYR, HA A, 65, GLY, O 3.40Å
B, 69, ALA, HA A, 66, TYR, OH 3.12Å
A, 62, ALA, HA B, 61, VAL, O 3.46Å
A, 65, GLY, HA1 B, 62, ALA, O 3.22Å
A, 66, TYR, HA B, 65, GLY, O 3.40Å
A, 69, ALA, HA B, 66, TYR, OH 3.12Å