Protein SERAC1

UniProt data

UniProt name: SRAC1_HUMAN (Q96JX3)

Gene name: SERAC1

Organism: Homo sapiens (Human).

Function: Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway. {ECO:0000269|PubMed:22683713}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:22683713}. Mitochondrion {ECO:0000269|PubMed:22683713}. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.

Transmembrane domains:

  1. 32-54, 23 AA, Helical. {ECO:0000255}.

Sequence: 654 AA

10 20 30 40 50 60 MSLAAYCVIC CRRIGTSTSP PKSGTHWRDI RNIIKFTGSL ILGGSLFLTY EVLALKKAVT 70 80 90 100 110 120 LDTQVVEREK MKSYIYVHTV SLDKGENHGI AWQARKELHK AVRKVLATSA KILRNPFADP 130 140 150 160 170 180 FSTVDIEDHE CAVWLLLRKS KSDDKTTRLE AVREMSETHH WHDYQYRIIA QACDPKTLIG 190 200 210 220 230 240 LARSEESDLR FFLLPPPLPS LKEDSSTEEE LRQLLASLPQ TELDECIQYF TSLALSESSQ 250 260 270 280 290 300 SLAAQKGGLW CFGGNGLPYA ESFGEVPSAT VEMFCLEAIV KHSEISTHCD KIEANGGLQL 310 320 330 340 350 360 LQRLYRLHKD CPKVQRNIMR VIGNMALNEH LHSSIVRSGW VSIMAEAMKS PHIMESSHAA 370 380 390 400 410 420 RILANLDRET VQEKYQDGVY VLHPQYRTSQ PIKADVLFIH GLMGAAFKTW RQQDSEQAVI 430 440 450 460 470 480 EKPMEDEDRY TTCWPKTWLA KDCPALRIIS VEYDTSLSDW RARCPMERKS IAFRSNELLR 490 500 510 520 530 540 KLRAAGVGDR PVVWISHSMG GLLVKKMLLE ASTKPEMSTV INNTRGIIFY SVPHHGSRLA 550 560 570 580 590 600 EYSVNIRYLL FPSLEVKELS KDSPALKTLQ DDFLEFAKDK NFQVLNFVET LPTYIGSMIK 610 620 630 640 650 LHVVPVESAD LGIGDLIPVD VNHLNICKPK KKDAFLYQRT LQFIREALAK DLEN

CATM prediction

The sequence of SRAC1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   30        40        50      
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 DIRNIIKFTGSLILGGSLFLTYEVLALKK 6.9 -48.1° 1.1 37.0 -22.7
Model 2 DIRNIIKFTGSLILGGSLFLTYEVLALKK 7.2 -48.9° 4.5 49.4 -7.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 43, GLY, HA1 A, 40, LEU, O 2.95Å
B, 44, GLY, HA2 A, 43, GLY, O 3.18Å
B, 48, LEU, HA A, 51, GLU, OE1 3.04Å
B, 48, LEU, HA A, 51, GLU, OE2 2.46Å
A, 43, GLY, HA1 B, 40, LEU, O 2.95Å
A, 44, GLY, HA2 B, 43, GLY, O 3.18Å