Cadherin-related family member 1

UniProt data

UniProt name: CDHR1_HUMAN (Q96JP9)

Gene name: CDHR1; Synonyms=KIAA1775, PCDH21, PRCAD

Organism: Homo sapiens (Human).

Function: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Localized at the junction between the inner and outer segments of rod and cone photoreceptors cells. Confined to the base of the OS. Localized on the edges of nascent evaginating disks on the side of the OS opposite the connecting cilium. Expressed at postnatal day 2 at the apical tip of the rod photoreceptor cells, the site of the developing OS. Colocalized with rhodopsin between postnatal days 2 and 9 at the base of the growing OS region (By similarity). {ECO:0000250}.

Transmembrane domains:

  1. 701-721, 21 AA, Helical. {ECO:0000255}.

Sequence: 859 AA

10 20 30 40 50 60 MRRCRWAALA LGLLRLCLAQ ANFAPHFFDN GVGSTNGNMA LFSLPEDTPV GSHVYTLNGT 70 80 90 100 110 120 DPEGDPISYH ISFDPSTRSV FSVDPTFGNI TLVEELDRER EDEIEAIISI SDGLNLVAEK 130 140 150 160 170 180 VVILVTDAND EAPRFIQEPY VALVPEDIPA GSIIFKVHAV DRDTGSGGSV TYFLQNLHSP 190 200 210 220 230 240 FAVDRHSGVL RLQAGATLDY ERSRTHYITV VAKDGGGRLH GADVVFSATT TVTVNVEDVQ 250 260 270 280 290 300 DMAPVFVGTP YYGYVYEDTL PGSEVLKVVA MDGDRGKPNR ILYSLVNGND GAFEINETSG 310 320 330 340 350 360 AISITQSPAQ LQREVYELHV QVTEMSPAGS PAAQATVPVT IRIVDLNNHP PTFYGESGPQ 370 380 390 400 410 420 NRFELSMNEH PPQGEILRGL KITVNDSDQG ANAKFNLQLV GPRGIFRVVP QTVLNEAQVT 430 440 450 460 470 480 IIVENSAAID FEKSKVLTFK LLAVEVNTPE KFSSTADVVI QLLDTNDNVP KFDSLYYVAR 490 500 510 520 530 540 IPENAPGGSS VVAVTAVDPD TGPWGEVKYS TYGTGADLFL IHPSTGLIYT QPWASLDAEA 550 560 570 580 590 600 TARYNFYVKA EDMEGKYSVA EVFITLLDVN DHPPQFGKSV QKKTMVLGTP VKIEAIDEDA 610 620 630 640 650 660 EEPNNLVDYS ITHAEPANVF DINSHTGEIW LKNSIRSLDA LHNITPGRDC LWSLEVQAKD 670 680 690 700 710 720 RGSPSFSTTA LLKIDITDAE TLSRSPMAAF LIQTKDNPMK AVGVLAGTMA TVVAITVLIS 730 740 750 760 770 780 TATFWRNKKS NKVLPMRRVL RKRPSPAPRT IRIEWLKSKS TKAATKFMLK EKPPNENCNN 790 800 810 820 830 840 NSPESSLLPR APALPPPPSV APSTGAAQWT VPTVSGSLTP QPTQPPPKPK TMGSPVQSTL 850 ISELKQKFEK KSVHNKAYF

CATM prediction

The sequence of CDHR1_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    700       710       720  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 AMKAVGVLAGTMATVVAITVLISTATF 6.6 -52.7° 4.2 54.1 -15.6
Model 2 AMKAVGVLAGTMATVVAITVLISTATF 7.1 -25.1° 2.7 52.0 -13.0
Model 3 AMKAVGVLAGTMATVVAITVLISTATF 7.2 -37.2° 2.3 35.9 -6.0
Model 4 AMKAVGVLAGTMATVVAITVLISTATF 7.3 -44.0° 1.8 44.8 -3.1
Model 5 AMKAVGVLAGTMATVVAITVLISTATF 7.1 -43.0° 3.5 50.0 -1.5
Prolines* PMKAVGVLAGTMATVVAITVLISTATF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 704, VAL, HA A, 703, GLY, O 2.61Å
B, 707, GLY, HA1 A, 704, VAL, O 2.90Å
B, 711, THR, HG1 A, 711, THR, OG1 2.42Å
A, 704, VAL, HA B, 703, GLY, O 2.61Å
A, 707, GLY, HA1 B, 704, VAL, O 2.90Å
A, 708, THR, HA B, 711, THR, OG1 3.14Å