Protein disulfide-isomerase TMX3

UniProt data

UniProt name: TMX3_HUMAN (Q96JJ7)

Gene name: TMX3; Synonyms=KIAA1830, TXNDC10

Organism: Homo sapiens (Human).

Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. {ECO:0000269|PubMed:15623505}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623505}; Single-pass membrane protein {ECO:0000269|PubMed:15623505}.

Transmembrane domains:

  1. 376-396, 21 AA, Helical. {ECO:0000255}.

Sequence: 454 AA

10 20 30 40 50 60 MAAWKSWTAL RLCATVVVLD MVVCKGFVED LDESFKENRN DDIWLVDFYA PWCGHCKKLE 70 80 90 100 110 120 PIWNEVGLEM KSIGSPVKVG KMDATSYSSI ASEFGVRGYP TIKLLKGDLA YNYRGPRTKD 130 140 150 160 170 180 DIIEFAHRVS GALIRPLPSQ QMFEHMQKRH RVFFVYVGGE SPLKEKYIDA ASELIVYTYF 190 200 210 220 230 240 FSASEEVVPE YVTLKEMPAV LVFKDETYFV YDEYEDGDLS SWINRERFQN YLAMDGFLLY 250 260 270 280 290 300 ELGDTGKLVA LAVIDEKNTS VEHTRLKSII QEVARDYRDL FHRDFQFGHM DGNDYINTLL 310 320 330 340 350 360 MDELTVPTVV VLNTSNQQYF LLDRQIKNVE DMVQFINNIL DGTVEAQGGD SILQRLKRIV 370 380 390 400 410 420 FDAKSTIVSI FKSSPLMGCF LFGLPLGVIS IMCYGIYTAD TDGGYIEERY EVSKSENENQ 430 440 450 EQIEESKEQQ EPSSGGSVVP TVQEPKDVLE KKKD

CATM prediction

The sequence of TMX3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         380       390       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SSALMGCFLFGLALGVISIMCYGIYTA 6.7 -54.9° 1.5 44.9 -31.2
Model 2 SSALMGCFLFGLALGVISIMCYGIYTA 7.0 -51.0° 2.4 45.0 -16.7
Model 3 SSALMGCFLFGLALGVISIMCYGIYTA 7.0 +51.0° 3.9 72.0 -5.7
Prolines* SSPLMGCFLFGLPLGVISIMCYGIYTA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 380, PHE, HA A, 379, CYS, O 3.31Å
B, 383, GLY, HA1 A, 380, PHE, O 2.67Å
B, 384, LEU, HA A, 383, GLY, O 3.04Å
A, 380, PHE, HA B, 379, CYS, O 3.31Å
A, 383, GLY, HA1 B, 380, PHE, O 2.67Å
A, 384, LEU, HA B, 383, GLY, O 3.04Å