Kin of IRRE-like protein 1

UniProt data

UniProt name: KIRR1_HUMAN (Q96J84)

Gene name: KIRREL; Synonyms=KIRREL1, NEPH1

Organism: Homo sapiens (Human).

Function: Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.

Transmembrane domains:

  1. 500-520, 21 AA, Helical. {ECO:0000255}.

Sequence: 757 AA

10 20 30 40 50 60 MLSLLVWILT LSDTFSQGTQ TRFSQEPADQ TVVAGQRAVL PCVLLNYSGI VQWTKDGLAL 70 80 90 100 110 120 GMGQGLKAWP RYRVVGSADA GQYNLEITDA ELSDDASYEC QATEAALRSR RAKLTVLIPP 130 140 150 160 170 180 EDTRIDGGPV ILLQAGTPHN LTCRAFNAKP AATIIWFRDG TQQEGAVAST ELLKDGKRET 190 200 210 220 230 240 TVSQLLINPT DLDIGRVFTC RSMNEAIPSG KETSIELDVH HPPTVTLSIE PQTVQEGERV 250 260 270 280 290 300 VFTCQATANP EILGYRWAKG GFLIEDAHES RYETNVDYSF FTEPVSCEVH NKVGSTNVST 310 320 330 340 350 360 LVNVHFAPRI VVDPKPTTTD IGSDVTLTCV WVGNPPLTLT WTKKDSNMVL SNSNQLLLKS 370 380 390 400 410 420 VTQADAGTYT CRAIVPRIGV AEREVPLYVN GPPIISSEAV QYAVRGDGGK VECFIGSTPP 430 440 450 460 470 480 PDRIAWAWKE NFLEVGTLER YTVERTNSGS GVLSTLTINN VMEADFQTHY NCTAWNSFGP 490 500 510 520 530 540 GTAIIQLEER EVLPVGIIAG ATIGASILLI FFFIALVFFL YRRRKGSRKD VTLRKLDIKV 550 560 570 580 590 600 ETVNREPLTM HSDREDDTAS VSTATRVMKA IYSSFKDDVD LKQDLRCDTI DTREEYEMKD 610 620 630 640 650 660 PTNGYYNVRA HEDRPSSRAV LYADYRAPGP ARFDGRPSSR LSHSSGYAQL NTYSRGPASD 670 680 690 700 710 720 YGPEPTPPGP AAPAGTDTTS QLSYENYEKF NSHPFPGAAG YPTYRLGYPQ APPSGLERTP 730 740 750 YEAYDPIGKY ATATRFSYTS QHSDYGQRFQ QRMQTHV

CATM prediction

The sequence of KIRR1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     500       510       520 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 IIAGATIGASILLIFFFIALVFFLYRR 6.5 -55.0° 4.2 37.9 -13.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 501, ALA, HA A, 500, GLY, O 2.48Å
B, 501, ALA, HA A, 501, ALA, O 3.47Å
B, 504, GLY, HA1 A, 501, ALA, O 2.71Å
A, 501, ALA, HA B, 500, GLY, O 2.48Å
A, 501, ALA, HA B, 501, ALA, O 3.47Å
A, 504, GLY, HA1 B, 501, ALA, O 2.71Å