UniProt data
UniProt name: VSIG2_HUMAN (Q96IQ7)
Gene name: VSIG2; Synonyms=CTH, CTXL; ORFNames=UNQ2770/PRO7154
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 244-264, 21 AA, Helical. {ECO:0000255}.
Sequence: 327 AA
10 20 30 40 50 60
MAELPGPFLC GALLGFLCLS GLAVEVKVPT EPLSTPLGKT AELTCTYSTS VGDSFALEWS
70 80 90 100 110 120
FVQPGKPISE SHPILYFTNG HLYPTGSKSK RVSLLQNPPT VGVATLKLTD VHPSDTGTYL
130 140 150 160 170 180
CQVNNPPDFY TNGLGLINLT VLVPPSNPLC SQSGQTSVGG STALRCSSSE GAPKPVYNWV
190 200 210 220 230 240
RLGTFPTPSP GSMVQDEVSG QLILTNLSLT SSGTYRCVAT NQMGSASCEL TLSVTEPSQG
250 260 270 280 290 300
RVAGALIGVL LGVLLLSVAA FCLVRFQKER GKKPKETYGG SDLREDAIAP GISEHTCMRA
310 320
DSSKGFLERP SSASTVTTTK SKLPMVV
CATM prediction
The sequence of VSIG2_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 250 260 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RVAGALIGVLLGVLLLSVAAFCLVRFQ | 6.4 | -29.0° | 4.7 | 51.7 | -32.2 |
| Model 2 | RVAGALIGVLLGVLLLSVAAFCLVRFQ | 6.5 | -43.1° | 3.5 | 49.5 | -20.9 |
| Model 3 | RVAGALIGVLLGVLLLSVAAFCLVRFQ | 7.0 | -54.9° | 5.8 | 47.4 | -3.9 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 245, ALA, HA | A, 244, GLY, O | 2.25Å |
| B, 248, GLY, HA1 | A, 245, ALA, O | 2.93Å |
| B, 249, VAL, HA | A, 248, GLY, O | 3.35Å |
| A, 245, ALA, HA | B, 244, GLY, O | 2.25Å |
| A, 248, GLY, HA1 | B, 245, ALA, O | 2.93Å |
| A, 249, VAL, HA | B, 248, GLY, O | 3.35Å |
