Cytochrome c oxidase assembly protein COX14

UniProt data

UniProt name: COX14_HUMAN (Q96I36)

Gene name: COX14; Synonyms=C12orf62

Organism: Homo sapiens (Human).

Function: Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1. {ECO:0000269|PubMed:22243966, ECO:0000269|PubMed:22356826}.

Subcellular location: Mitochondrion membrane {ECO:0000269|PubMed:22243966, ECO:0000269|PubMed:22356826}; Single-pass membrane protein {ECO:0000269|PubMed:22243966, ECO:0000269|PubMed:22356826}.

Transmembrane domains:

  1. 15-37, 23 AA, Helical. {ECO:0000255}.

Sequence: 57 AA

10 20 30 40 50 MPTGKQLADI GYKTFSTSMM LLTVYGGYLC SVRVYHYFQW RRAQRQAAEE QKTSGIM

CATM prediction

The sequence of COX14_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          20        30        4
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 YKTFSTSMMLLTVYGGYLCSVRVYHYFQW 7.3 -47.0° 2.2 45.3 -8.3
Model 2 YKTFSTSMMLLTVYGGYLCSVRVYHYFQW 6.8 -51.0° 1.2 45.1 -7.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 24, VAL, HA A, 23, THR, O 3.36Å
B, 27, GLY, HA1 A, 24, VAL, O 3.20Å
B, 31, SER, HA A, 28, TYR, OH 3.03Å
A, 24, VAL, HA B, 23, THR, O 3.36Å
A, 27, GLY, HA1 B, 24, VAL, O 3.20Å
A, 31, SER, HA B, 28, TYR, OH 3.03Å