UniProt data
UniProt name: RUS1_HUMAN (Q96GQ5)
Gene name: C16orf58
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 247-267, 21 AA, Helical. {ECO:0000255}.
Sequence: 468 AA
10 20 30 40 50 60
MADDAGLETP LCSEQFGSGE ARGCRAAADG SLQWEVGGWR WWGLSRAFTV KPEGRDAGEV
70 80 90 100 110 120
GASGAPSPPL SGLQAVFLPQ GFPDSVSPDY LPYQLWDSVQ AFASSLSGSL ATQAVLLGIG
130 140 150 160 170 180
VGNAKATVSA ATATWLVKDS TGMLGRIVFA WWKGSKLDCN AKQWRLFADI LNDVAMFLEI
190 200 210 220 230 240
MAPVYPICFT MTVSTSNLAK CIVSVAGGAT RAALTVHQAR RNNMADVSAK DSSQETLVNL
250 260 270 280 290 300
AGLLVSLLML PLVSGCPGFS LGCFFFLTAL HIYANYRAVR ALVMETLNEG RLRLVLKHYL
310 320 330 340 350 360
QRGEVLDPTA ANRMEPLWTG FWPAPSLSLG VPLHRLVSSV FELQQLVEGH QESYLLCWDQ
370 380 390 400 410 420
SQNQVQVVLN QKAGPKTILR AATHGLMLGA LQGDGPLPAE LEELRNRVRA GPKKESWVVV
430 440 450 460
KETHEVLDML FPKFLKGLQD AGWKTEKHQL EVDEWRATWL LSPEKKVL
CATM prediction
The sequence of RUS1_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 250 260 2 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LVSLLMLALVSGCAGFSLGCFFFLTAL | 6.8 | -43.2° | 2.4 | 44.0 | -32.3 |
| Model 2 | LVSLLMLALVSGCAGFSLGCFFFLTAL | 6.9 | -55.0° | 2.4 | 48.1 | -25.9 |
| Model 3 | LVSLLMLALVSGCAGFSLGCFFFLTAL | 7.0 | +52.9° | 2.1 | 95.8 | -18.6 |
| Model 4 | LVSLLMLALVSGCAGFSLGCFFFLTAL | 6.8 | -55.2° | 2.4 | 48.1 | -18.4 |
| Prolines* | LVSLLMLPLVSGCPGFSLGCFFFLTAL |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 251, ALA, HA | A, 254, SER, OG | 3.12Å |
| B, 255, GLY, HA2 | A, 254, SER, O | 2.85Å |
| B, 258, GLY, HA1 | A, 255, GLY, O | 2.76Å |
| B, 259, PHE, HA | A, 258, GLY, O | 3.20Å |
| A, 251, ALA, HA | B, 254, SER, OG | 3.49Å |
| A, 255, GLY, HA2 | B, 254, SER, O | 2.85Å |
| A, 258, GLY, HA1 | B, 255, GLY, O | 2.76Å |
| A, 259, PHE, HA | B, 258, GLY, O | 3.20Å |
