Scavenger receptor class F member 2

UniProt data

UniProt name: SREC2_HUMAN (Q96GP6)

Gene name: SCARF2; Synonyms=SREC2, SREPCR

Organism: Homo sapiens (Human).

Function: Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL) (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 442-462, 21 AA, Helical. {ECO:0000255}.

Sequence: 870 AA

10 20 30 40 50 60 MEGAGPRGAG PARRRGAGGP PSPLLPSLLL LLLLWMLPDT VAPQELNPRG RNVCRAPGSQ 70 80 90 100 110 120 VPTCCAGWRQ QGDECGIAVC EGNSTCSENE VCVRPGECRC RHGYFGANCD TKCPRQFWGP 130 140 150 160 170 180 DCKELCSCHP HGQCEDVTGQ CTCHARRWGA RCEHACQCQH GTCHPRSGAC RCEPGWWGAQ 190 200 210 220 230 240 CASACYCSAT SRCDPQTGAC LCHAGWWGRS CNNQCACNSS PCEQQSGRCQ CRERTFGARC 250 260 270 280 290 300 DRYCQCFRGR CHPVDGTCAC EPGYRGKYCR EPCPAGFYGL GCRRRCGQCK GQQPCTVAEG 310 320 330 340 350 360 RCLTCEPGWN GTKCDQPCAT GFYGEGCSHR CPPCRDGHAC NHVTGKCTRC NAGWIGDRCE 370 380 390 400 410 420 TKCSNGTYGE DCAFVCADCG SGHCDFQSGR CLCSPGVHGP HCNVTCPPGL HGADCAQACS 430 440 450 460 470 480 CHEDTCDPVT GACHLETNQR KGVMGAGALL VLLVCLLLSL LGCCCACRGK DPTRRPRPRR 490 500 510 520 530 540 ELSLGRKKAP HRLCGRFSRI SMKLPRIPLR RQKLPKVVVA HHDLDNTLNC SFLEPPSGLE 550 560 570 580 590 600 QPSPSWSSRA SFSSFDTTDE GPVYCVPHEE APAESRDPEV PTVPAEAPAP SPVPLTTPAS 610 620 630 640 650 660 AEEAIPLPAS SDSERSASSV EGPGGALYAR VARREARPAR ARGEIGGLSL SPSPERRKPP 670 680 690 700 710 720 PPDPATKPKV SWIHGKHSAA AAGRAPSPPP PGSEAAPSPS KRKRTPSDKS AHTVEHGSPR 730 740 750 760 770 780 TRDPTPRPPG LPEEATALAA PSPPRARARA APRPLGAHGR RRSPAKRAEA ASMLAADVRG 790 800 810 820 830 840 KTRSLGRAEV ALGAQGPREK PAPPQKAKRS VPPASPARAP PATETPGPEK AATDLPAPET 850 860 PRKKTPIQKP PRKKSREAAG ELGRAGAPTL

CATM prediction

The sequence of SREC2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   440       450       460   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 QRKGVMGAGALLVLLVCLLLSLLGCCC 6.5 -49.0° 3.9 38.0 -7.0
Model 2 QRKGVMGAGALLVLLVCLLLSLLGCCC 7.4 -46.1° 3.6 37.0 -4.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 445, GLY, HA1 A, 442, GLY, O 2.64Å
A, 445, GLY, HA1 B, 442, GLY, O 2.64Å