Melanocortin-2 receptor accessory protein 2

UniProt data

UniProt name: MRAP2_HUMAN (Q96G30)

Gene name: MRAP2; Synonyms=C6orf117

Organism: Homo sapiens (Human).

Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. {ECO:0000250, ECO:0000269|PubMed:19329486, ECO:0000269|PubMed:20371771}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19329486}; Single-pass membrane protein {ECO:0000269|PubMed:19329486}. Note=The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context. {ECO:0000269|PubMed:20371771}.

Transmembrane domains:

  1. 45-65, 21 AA, Helical. {ECO:0000255}.

Sequence: 205 AA

10 20 30 40 50 60 MSAQRLISNR TSQQSASNSD YTWEYEYYEI GPVSFEGLKA HKYSIVIGFW VGLAVFVIFM 70 80 90 100 110 120 FFVLTLLTKT GAPHQDNAES SEKRFRMNSF VSDFGRPLEP DKVFSRQGNE ESRSLFHCYI 130 140 150 160 170 180 NEVERLDRAK ACHQTTALDS DVQLQEAIRS SGQPEEELNR LMKFDIPNFV NTDQNYFGED 190 200 DLLISEPPIV LETKPLSQTS HKDLD

CATM prediction

The sequence of MRAP2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          50        60       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 KYSIVIGFWVGLAVFVIFMFFVLTLLT 7.4 -46.1° 3.6 37.3 -28.9
Model 2 KYSIVIGFWVGLAVFVIFMFFVLTLLT 7.0 -29.0° 2.5 60.0 -8.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 48, GLY, HA1 A, 45, ILE, O 3.00Å
B, 49, PHE, HA A, 48, GLY, O 3.43Å
A, 48, GLY, HA1 B, 45, ILE, O 3.00Å
A, 49, PHE, HA B, 48, GLY, O 3.43Å