Phosphoinositide-3-kinase-interacting protein 1

UniProt data

UniProt name: P3IP1_HUMAN (Q96FE7)

Gene name: PIK3IP1; Synonyms=HGFL

Organism: Homo sapiens (Human).

Function: Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19088825}; Single-pass type I membrane protein {ECO:0000269|PubMed:19088825}.

Transmembrane domains:

  1. 169-189, 21 AA, Helical. {ECO:0000255}.

Sequence: 263 AA

10 20 30 40 50 60 MLLAWVQAFL VSNMLLAEAY GSGGCFWDNG HLYREDQTSP APGLRCLNWL DAQSGLASAP 70 80 90 100 110 120 VSGAGNHSYC RNPDEDPRGP WCYVSGEAGV PEKRPCEDLR CPETTSQALP AFTTEIQEAS 130 140 150 160 170 180 EGPGADEVQV FAPANALPAR SEAAAVQPVI GISQRVRMNS KEKKDLGTLG YVLGITMMVI 190 200 210 220 230 240 IIAIGAGIIL GYSYKRGKDL KEQHDQKVCE REMQRITLPL SAFTNPTCEI VDEKTVVVHT 250 260 SQTPVDPQEG TTPLMGQAGT PGA

CATM prediction

The sequence of P3IP1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      170       180       190
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LGTLGYVLGITMMVIIIAIGAGIILGY 7.0 -54.1° 2.8 51.2 -25.6
Model 2 LGTLGYVLGITMMVIIIAIGAGIILGY 6.6 -28.0° 3.1 48.0 -21.4
Model 3 LGTLGYVLGITMMVIIIAIGAGIILGY 6.8 +38.0° 4.0 77.0 -15.0
Model 4 LGTLGYVLGITMMVIIIAIGAGIILGY 7.4 -40.0° 4.0 38.0 -10.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 171, TYR, HA A, 170, GLY, O 3.11Å
B, 174, GLY, HA1 A, 171, TYR, O 3.00Å
A, 171, TYR, HA B, 170, GLY, O 3.11Å
A, 174, GLY, HA1 B, 171, TYR, O 3.00Å