UDP-N-acetylglucosamine transferase subunit ALG14 homolog

UniProt data

UniProt name: ALG14_HUMAN (Q96F25)

Gene name: ALG14

Organism: Homo sapiens (Human).

Function: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER. {ECO:0000269|PubMed:16100110}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P38242}; Single-pass membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 4-24, 21 AA, Helical. {ECO:0000255}.

Sequence: 216 AA

10 20 30 40 50 60 MVCVLVLAAA AGAVAVFLIL RIWVVLRSMD VTPRESLSIL VVAGSGGHTT EILRLLGSLS 70 80 90 100 110 120 NAYSPRHYVI ADTDEMSANK INSFELDRAD RDPSNMYTKY YIHRIPRSRE VQQSWPSTVF 130 140 150 160 170 180 TTLHSMWLSF PLIHRVKPDL VLCNGPGTCV PICVSALLLG ILGIKKVIIV YVESICRVET 190 200 210 LSMSGKILFH LSDYFIVQWP ALKEKYPKSV YLGRIV

CATM prediction

The sequence of ALG14_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           10        20      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 MVCVLVLAAAAGAVAVFLILRIWVVLR 7.1 -49.7° 2.9 46.7 -8.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 9, ALA, HA A, 8, ALA, O 3.00Å
B, 12, GLY, HA1 A, 9, ALA, O 2.97Å
A, 9, ALA, HA B, 8, ALA, O 3.00Å
A, 12, GLY, HA1 B, 9, ALA, O 2.97Å