UniProt data
UniProt name: SIM12_HUMAN (Q96EX1)
Gene name: SMIM12; Synonyms=C1orf212
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 15-34, 20 AA, Helical. {ECO:0000255}.
Sequence: 92 AA
CATM prediction
The sequence of SIM12_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 20 30 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | YAAYVTFAVAFVVGAVGYHLEWFIRG | 7.0 | -40.0° | 2.7 | 33.9 | -10.2 |
| Model 2 | YAAYVTFAVAFVVGAVGYHLEWFIRG | 7.0 | -54.4° | 2.9 | 50.8 | -3.7 |
| Model 3 | YAAYVTFAVAFVVGAVGYHLEWFIRG | 7.0 | +47.8° | 1.9 | -0.5 | -0.9 |
| Prolines* | YAPYVTFPVAFVVGAVGYHLEWFIRG |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 25, GLY, HA2 | A, 24, VAL, O | 3.22Å |
| B, 28, GLY, HA1 | A, 25, GLY, O | 3.06Å |
| B, 29, TYR, HA | A, 28, GLY, O | 3.43Å |
| B, 33, TRP, HA | A, 32, GLU, OE2 | 3.36Å |
| A, 25, GLY, HA2 | B, 24, VAL, O | 3.22Å |
| A, 28, GLY, HA1 | B, 25, GLY, O | 3.06Å |
| A, 29, TYR, HA | B, 28, GLY, O | 3.43Å |
| A, 33, TRP, HA | B, 32, GLU, OE2 | 3.34Å |
