C1GALT1-specific chaperone 1

UniProt data

UniProt name: C1GLC_HUMAN (Q96EU7)

Gene name: C1GALT1C1; Synonyms=COSMC

Organism: Homo sapiens (Human).

Function: Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1). {ECO:0000269|PubMed:12464682}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 7-26, 20 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 318 AA

10 20 30 40 50 60 MLSESSSFLK GVMLGSIFCA LITMLGHIRI GHGNRMHHHE HHHLQAPNKE DILKISEDER 70 80 90 100 110 120 MELSKSFRVY CIILVKPKDV SLWAAVKETW TKHCDKAEFF SSENVKVFES INMDTNDMWL 130 140 150 160 170 180 MMRKAYKYAF DKYRDQYNWF FLARPTTFAI IENLKYFLLK KDPSQPFYLG HTIKSGDLEY 190 200 210 220 230 240 VGMEGGIVLS VESMKRLNSL LNIPEKCPEQ GGMIWKISED KQLAVCLKYA GVFAENAEDA 250 260 270 280 290 300 DGKDVFNTKS VGLSIKEAMT YHPNQVVEGC CSDMAVTFNG LTPNQMHVMM YGVYRLRAFG 310 HIFNDALVFL PPNGSDND

CATM prediction

The sequence of C1GLC_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        
 +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ESSSFLKGVMLGSIFCALITMLGHIR 7.1 -27.8° 3.2 47.9 -41.1
Model 2 ESSSFLKGVMLGSIFCALITMLGHIR 6.6 -46.4° 6.0 58.8 -22.9
Model 3 ESSSFLKGVMLGSIFCALITMLGHIR 6.8 -46.9° 2.2 45.1 -10.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, PHE, HA A, 7, SER, O 2.87Å
B, 11, GLY, HA1 A, 8, PHE, O 3.24Å
B, 12, VAL, HA A, 11, GLY, O 3.35Å
A, 8, PHE, HA B, 7, SER, O 2.87Å
A, 11, GLY, HA1 B, 8, PHE, O 3.24Å
A, 12, VAL, HA B, 11, GLY, O 3.35Å