Killer cell lectin-like receptor subfamily G member 1

UniProt data

UniProt name: KLRG1_HUMAN (Q96E93)

Gene name: KLRG1; Synonyms=CLEC15A, MAFA, MAFAL

Organism: Homo sapiens (Human).

Function: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}.

Transmembrane domains:

  1. 39-59, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 195 AA

10 20 30 40 50 60 MTDSVIYSML ELPTATQAQN DYGPQQKSSS SRPSCSCLVA IALGLLTAVL LSVLLYQWIL 70 80 90 100 110 120 CQGSNYSTCA SCPSCPDRWM KYGNHCYYFS VEEKDWNSSL EFCLARDSHL LVITDNQEMS 130 140 150 160 170 180 LLQVFLSEAF CWIGLRNNSG WRWEDGSPLN FSRISSNSFV QTCGAINKNG LQASSCEVPL 190 HWVCKKCPFA DQALF

CATM prediction

The sequence of KLRG1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      40        50        60 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 SCLVAIALGLLTAVLLSVLLYQWILCQ 7.0 -45.9° 2.7 46.9 -33.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 41, ILE, HA A, 40, ALA, O 2.91Å
B, 44, GLY, HA1 A, 41, ILE, O 2.83Å
B, 45, LEU, HA A, 44, GLY, O 3.33Å
A, 41, ILE, HA B, 40, ALA, O 2.91Å
A, 44, GLY, HA1 B, 41, ILE, O 2.83Å
A, 45, LEU, HA B, 44, GLY, O 3.33Å
A, 56, TYR, HH B, 56, TYR, OH 2.14Å