SLAM family member 6

UniProt data

UniProt name: SLAF6_HUMAN (Q96DU3)

Gene name: SLAMF6; Synonyms=KALI; ORFNames=UNQ6123/PRO20080

Organism: Homo sapiens (Human).

Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727, PubMed:16920955). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 227-247, 21 AA, Helical. {ECO:0000255}.

Sequence: 332 AA

10 20 30 40 50 60 MLWLFQSLLF VFCFGPGNVV SQSSLTPLMV NGILGESVTL PLEFPAGEKV NFITWLFNET 70 80 90 100 110 120 SLAFIVPHET KSPEIHVTNP KQGKRLNFTQ SYSLQLSNLK MEDTGSYRAQ ISTKTSAKLS 130 140 150 160 170 180 SYTLRILRQL RNIQVTNHSQ LFQNMTCELH LTCSVEDADD NVSFRWEALG NTLSSQPNLT 190 200 210 220 230 240 VSWDPRISSE QDYTCIAENA VSNLSFSVSA QKLCEDVKIQ YTDTKMILFM VSGICIVFGF 250 260 270 280 290 300 IILLLLVLRK RRDSLSLSTQ RTQGPAESAR NLEYVSVSPT NNTVYASVTH SNRETEIWTP 310 320 330 RENDTITIYS TINHSKESKP TFSRATALDN VV

CATM prediction

The sequence of SLAF6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        230       240       2
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 TKMILFMVSGICIVFGFIILLLLVLRK 7.4 -51.0° 3.3 48.1 -4.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 230, MET, HA A, 229, PHE, O 3.41Å
B, 233, GLY, HA1 A, 230, MET, O 3.48Å
A, 230, MET, HA B, 229, PHE, O 3.41Å
A, 233, GLY, HA1 B, 230, MET, O 3.48Å