Hepatitis A virus cellular receptor 1

UniProt data

UniProt name: HAVR1_HUMAN (Q96D42)

Gene name: HAVCR1; Synonyms=KIM1, TIM1, TIMD1

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for hepatitis A virus (PubMed:9658108). Acts as a receptor for ebolavirus and marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). {ECO:0000269|PubMed:21536871, ECO:0000269|PubMed:23084921, ECO:0000269|PubMed:9658108}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 291-311, 21 AA, Helical. {ECO:0000255}.

Sequence: 359 AA

10 20 30 40 50 60 MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWNRG SCSLFTCQNG 70 80 90 100 110 120 IVWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV 130 140 150 160 170 180 SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPTTT VPTTMSIPTT TTVLTTMTVS 190 200 210 220 230 240 TTTSVPTTTS IPTTTSVPVT TTVSTFVPPM PLPRQNHEPV ATSPSSPQPA ETHPTTLQGA 250 260 270 280 290 300 IRREPTSSPL YSYTTDGNDT VTESSDGLWN NNQTQLFLEH SLLTANTTKG IYAGVCISVL 310 320 330 340 350 VLLALLGVII AKKYFFKKEV QQLSVSFSSL QIKALQNAVE KEVQAEDNIY IENSLYATD

CATM prediction

The sequence of HAVR1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    290       300       310  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 TKGIYAGVCISVLVLLALLGVIIAKKY 6.6 -53.0° 4.2 53.9 -19.9
Model 2 TKGIYAGVCISVLVLLALLGVIIAKKY 7.4 -41.8° 2.8 50.0 -11.4
Model 3 TKGIYAGVCISVLVLLALLGVIIAKKY 7.3 -48.0° 0.5 46.8 -10.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 294, GLY, HA1 A, 291, ILE, O 2.79Å
B, 295, VAL, HA A, 298, SER, OG 3.01Å
A, 294, GLY, HA1 B, 291, ILE, O 2.79Å
A, 298, SER, HG1 B, 298, SER, OG 2.03Å