FAD-dependent oxidoreductase domain-containing protein 1 {ECO:0000312|HGNC:HGNC:26927}

UniProt data

UniProt name: FXRD1_HUMAN (Q96CU9)

Gene name: FOXRED1 {ECO:0000312|HGNC:HGNC:26927}; ORFNames=FP634

Organism: Homo sapiens (Human).

Function: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). {ECO:0000269|PubMed:20858599, ECO:0000269|PubMed:25678554}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:20858599, ECO:0000305|PubMed:25678554}; Single-pass membrane protein {ECO:0000255}. Note=According to a report, it is associated with the matrix face of the mitochondrial inner membrane and does not contain any transmembrane region. However, one transmembrane domain is clearly predicted by different methods (Probable). {ECO:0000305|PubMed:25678554}.

Transmembrane domains:

  1. 62-82, 21 AA, Helical. {ECO:0000255}.

Sequence: 486 AA

10 20 30 40 50 60 MIRRVLPHGM GRGLLTRRPG TRRGGFSLDW DGKVSEIKKK IKSILPGRSC DLLQDTSHLP 70 80 90 100 110 120 PEHSDVVIVG GGVLGLSVAY WLKKLESRRG AIRVLVVERD HTYSQASTGL SVGGICQQFS 130 140 150 160 170 180 LPENIQLSLF SASFLRNINE YLAVVDAPPL DLRFNPSGYL LLASEKDAAA MESNVKVQRQ 190 200 210 220 230 240 EGAKVSLMSP DQLRNKFPWI NTEGVALASY GMEDEGWFDP WCLLQGLRRK VQSLGVLFCQ 250 260 270 280 290 300 GEVTRFVSSS QRMLTTDDKA VVLKRIHEVH VKMDRSLEYQ PVECAIVINA AGAWSAQIAA 310 320 330 340 350 360 LAGVGEGPPG TLQGTKLPVE PRKRYVYVWH CPQGPGLETP LVADTSGAYF RREGLGSNYL 370 380 390 400 410 420 GGRSPTEQEE PDPANLEVDH DFFQDKVWPH LALRVPAFET LKVQSAWAGY YDYNTFDQNG 430 440 450 460 470 480 VVGPHPLVVN MYFATGFSGH GLQQAPGIGR AVAEMVLKGR FQTIDLSPFL FTRFYLGEKI QENNII

CATM prediction

The sequence of FXRD1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   60        70        80    
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 LAAEHSDVVIVGGGVLGLSVAYWLKKL 6.4 -46.8° 4.8 56.2 -7.8
Prolines* LPPEHSDVVIVGGGVLGLSVAYWLKKL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 71, GLY, HA1 A, 68, ILE, O 2.95Å
B, 72, GLY, HA2 A, 71, GLY, O 2.33Å
B, 75, GLY, HA1 A, 72, GLY, O 2.94Å
A, 71, GLY, HA1 B, 68, ILE, O 2.95Å
A, 72, GLY, HA2 B, 71, GLY, O 2.33Å
A, 75, GLY, HA1 B, 72, GLY, O 2.94Å