Mitochondrial dynamics protein MID49

UniProt data

UniProt name: MID49_HUMAN (Q96C03)

Gene name: MIEF2; Synonyms=MID49, SMCR7

Organism: Homo sapiens (Human).

Function: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269|PubMed:21508961, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:23921378}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:21508961}; Single-pass membrane protein {ECO:0000269|PubMed:21508961}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.

Transmembrane domains:

  1. 23-43, 21 AA, Helical. {ECO:0000255}.

Sequence: 454 AA

10 20 30 40 50 60 MAEFSQKRGK RRSDEGLGSM VDFLLANARL VLGVGGAAVL GIATLAVKRF IDRATSPRDE 70 80 90 100 110 120 DDTKADSWKE LSLLKATPHL QPRPPPAALS QPVLPLAPSS SAPEGPAETD PEVTPQLSSP 130 140 150 160 170 180 APLCLTLQER LLAFERDRVT IPAAQVALAK QLAGDIALEL QAYFRSKFPE LPFGAFVPGG 190 200 210 220 230 240 PLYDGLQAGA ADHVRLLVPL VLEPGLWSLV PGVDTVARDP RCWAVRRTQL EFCPRGSSPW 250 260 270 280 290 300 DRFLVGGYLS SRVLLELLRK ALAASVNWPA IGSLLGCLIR PSMASEELLL EVQHERLELT 310 320 330 340 350 360 VAVLVAVPGV DADDRLLLAW PLEGLAGNLW LQDLYPVEAA RLRALDDHDA GTRRRLLLLL 370 380 390 400 410 420 CAVCRGCSAL GQLGRGHLTQ VVLRLGEDNV DWTEEALGER FLQALELLIG SLEQASLPCH 430 440 450 FNPSVNLFSS LREEEIDDIG YALYSGLQEP EGLL

CATM prediction

The sequence of MID49_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  20        30        40     
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 MVDFLLANARLVLGVGGAAVLGIATLA 7.3 -38.0° 3.1 35.2 -20.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 29, ARG, HH21 A, 27, ASN, OD1 1.88Å
B, 30, LEU, HA A, 29, ARG, O 3.40Å
B, 33, GLY, HA1 A, 30, LEU, O 3.31Å
A, 29, ARG, HH21 B, 27, ASN, OD1 1.88Å
A, 30, LEU, HA B, 29, ARG, O 3.40Å
A, 33, GLY, HA1 B, 30, LEU, O 3.31Å