Transmembrane and immunoglobulin domain-containing protein 2

UniProt data

UniProt name: TMIG2_HUMAN (Q96BF3)

Gene name: TMIGD2; Synonyms=CD28H, IGPR1; ORFNames=UNQ3059/PRO9879

Organism: Homo sapiens (Human).

Function: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:22419821, ECO:0000269|PubMed:23784006}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22419821}; Single-pass type I membrane protein {ECO:0000269|PubMed:22419821}.

Transmembrane domains:

  1. 151-171, 21 AA, Helical. {ECO:0000255}.

Sequence: 282 AA

10 20 30 40 50 60 MGSPGMVLGL LVQIWALQEA SSLSVQQGPN LLQVRQGSQA TLVCQVDQAT AWERLRVKWT 70 80 90 100 110 120 KDGAILCQPY ITNGSLSLGV CGPQGRLSWQ APSHLTLQLD PVSLNHSGAY VCWAAVEIPE 130 140 150 160 170 180 LEEAEGNITR LFVDPDDPTQ NRNRIASFPG FLFVLLGVGS MGVAAIVWGA WFWGRRSCQQ 190 200 210 220 230 240 RDSGNSPGNA FYSNVLYRPR GAPKKSEDCS GEGKDQRGQS IYSTSFPQPA PRQPHLASRP 250 260 270 280 CPSPRPCPSP RPGHPVSMVR VSPRPSPTQQ PRPKGFPKVG EE

CATM prediction

The sequence of TMIG2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    150       160       170  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 FAGFLFVLLGVGSMGVAAIVWGAWFWG 7.0 -49.9° 2.9 46.9 -30.1
Prolines* FPGFLFVLLGVGSMGVAAIVWGAWFWG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 154, VAL, HA A, 153, PHE, O 3.10Å
B, 157, GLY, HA1 A, 154, VAL, O 3.00Å
A, 154, VAL, HA B, 153, PHE, O 3.10Å
A, 157, GLY, HA1 B, 154, VAL, O 3.00Å