Cyclic AMP-responsive element-binding protein 3-like protein 1

UniProt data

UniProt name: CR3L1_HUMAN (Q96BA8)

Gene name: CREB3L1; Synonyms=OASIS; ORFNames=PSEC0238

Organism: Homo sapiens (Human).

Function: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). {ECO:0000269|PubMed:21767813}.

Subcellular location: Processed cyclic AMP-responsive element- binding protein 3-like protein 1: Nucleus {ECO:0000269|PubMed:24079343, ECO:0000269|PubMed:25310401}. Note=Upon ER stress, transported into the nucleus. {ECO:0000269|PubMed:12054625, ECO:0000269|PubMed:21767813, ECO:0000269|PubMed:24079343, ECO:0000269|PubMed:25310401}.

Transmembrane domains:

  1. 375-395, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 519 AA

10 20 30 40 50 60 MDAVLEPFPA DRLFPGSSFL DLGDLNESDF LNNAHFPEHL DHFTENMEDF SNDLFSSFFD 70 80 90 100 110 120 DPVLDEKSPL LDMELDSPTP GIQAEHSYSL SGDSAPQSPL VPIKMEDTTQ DAEHGAWALG 130 140 150 160 170 180 HKLCSIMVKQ EQSPELPVDP LAAPSAMAAA AAMATTPLLG LSPLSRLPIP HQAPGEMTQL 190 200 210 220 230 240 PVIKAEPLEV NQFLKVTPED LVQMPPTPPS SHGSDSDGSQ SPRSLPPSSP VRPMARSSTA 250 260 270 280 290 300 ISTSPLLTAP HKLQGTSGPL LLTEEEKRTL IAEGYPIPTK LPLTKAEEKA LKRVRRKIKN 310 320 330 340 350 360 KISAQESRRK KKEYVECLEK KVETFTSENN ELWKKVETLE NANRTLLQQL QKLQTLVTNK 370 380 390 400 410 420 ISRPYKMAAT QTGTCLMVAA LCFVLVLGSL VPCLPEFSSG SQTVKEDPLA ADGVYTASQM 430 440 450 460 470 480 PSRSLLFYDD GAGLWEDGRS TLLPMEPPDG WEINPGGPAE QRPRDHLQHD HLDSTHETTK 490 500 510 YLSEAWPKDG GNGTSPDFSH SKEWFHDRDL GPNTTIKLS

CATM prediction

The sequence of CR3L1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          380       390      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 TGTCLMVAALCFVLVLGSLVACLAEFS 7.0 -46.8° 1.4 44.8 -18.0
Prolines* TGTCLMVAALCFVLVLGSLVPCLPEFS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 385, LEU, HA A, 384, VAL, O 3.30Å
B, 388, GLY, HA1 A, 385, LEU, O 2.95Å
B, 389, SER, HA A, 388, GLY, O 3.28Å
A, 385, LEU, HA B, 384, VAL, O 3.30Å
A, 388, GLY, HA1 B, 385, LEU, O 2.95Å
A, 389, SER, HA B, 388, GLY, O 3.28Å