Vesicular, overexpressed in cancer, prosurvival protein 1

UniProt data

UniProt name: VOPP1_HUMAN (Q96AW1)

Gene name: VOPP1; Synonyms=ECOP, GASP

Organism: Homo sapiens (Human).

Function: Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. {ECO:0000269|PubMed:15735698}.

Subcellular location: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:20571887}; Single-pass type I membrane protein {ECO:0000269|PubMed:20571887}. Note=When overexpressed, localizes in the nucleus and perinuclear regions.

Transmembrane domains:

  1. 61-81, 21 AA, Helical. {ECO:0000255}.

Sequence: 172 AA

10 20 30 40 50 60 MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL 70 80 90 100 110 120 WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT 130 140 150 160 170 DPGGPGMNPV GNSMAMAFQV PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK

CATM prediction

The sequence of VOPP1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    60        70        80   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 QRLWYFWFLLMMGVLFCCGAGFFIRRR 7.4 -47.0° 2.3 45.0 -15.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 67, LEU, HA A, 66, LEU, O 3.49Å
B, 70, GLY, HA1 A, 67, LEU, O 3.33Å
A, 67, LEU, HA B, 66, LEU, O 3.49Å
A, 70, GLY, HA1 B, 67, LEU, O 3.33Å