Endothelial cell-selective adhesion molecule

UniProt data

UniProt name: ESAM_HUMAN (Q96AP7)

Gene name: ESAM; ORFNames=UNQ220/PRO246

Organism: Homo sapiens (Human).

Function: Can mediate aggregation most likely through a homophilic molecular interaction. {ECO:0000250}.

Subcellular location: Cell junction, adherens junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 249-269, 21 AA, Helical. {ECO:0000255}.

Sequence: 390 AA

10 20 30 40 50 60 MISLPGPLVT NLLRFLFLGL SALAPPSRAQ LQLHLPANRL QAVEGGEVVL PAWYTLHGEV 70 80 90 100 110 120 SSSQPWEVPF VMWFFKQKEK EDQVLSYING VTTSKPGVSL VYSMPSRNLS LRLEGLQEKD 130 140 150 160 170 180 SGPYSCSVNV QDKQGKSRGH SIKTLELNVL VPPAPPSCRL QGVPHVGANV TLSCQSPRSK 190 200 210 220 230 240 PAVQYQWDRQ LPSFQTFFAP ALDVIRGSLS LTNLSSSMAG VYVCKAHNEV GTAQCNVTLE 250 260 270 280 290 300 VSTGPGAAVV AGAVVGTLVG LGLLAGLVLL YHRRGKALEE PANDIKEDAI APRTLPWPKS 310 320 330 340 350 360 SDTISKNGTL SSVTSARALR PPHGPPRPGA LTPTPSLSSQ ALPSPRLPTT DGAHPQPISP 370 380 IPGGVSSSGL SRMGAVPVMV PAQSQAGSLV

CATM prediction

The sequence of ESAM_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      250       260       270
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GAAVVAGAVVGTLVGLGLLAGLVLLYH 6.3 -37.9° 2.9 60.8 -43.0
Model 2 GAAVVAGAVVGTLVGLGLLAGLVLLYH 6.4 -48.0° 0.5 47.0 -30.5
Model 3 GAAVVAGAVVGTLVGLGLLAGLVLLYH 7.0 -29.3° 2.6 60.3 -24.5
Model 4 GAAVVAGAVVGTLVGLGLLAGLVLLYH 6.9 -54.0° 2.5 33.0 -14.5
Model 5 GAAVVAGAVVGTLVGLGLLAGLVLLYH 6.9 -55.0° 1.5 44.8 -9.7
Model 6 GAAVVAGAVVGTLVGLGLLAGLVLLYH 7.2 -54.0° 2.9 51.0 -7.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 252, GLY, HA1 A, 249, VAL, O 3.19Å
B, 253, ALA, HA A, 252, GLY, O 2.40Å
B, 256, GLY, HA1 A, 253, ALA, O 2.77Å
B, 257, THR, HA A, 256, GLY, O 3.21Å
A, 252, GLY, HA1 B, 249, VAL, O 3.19Å
A, 253, ALA, HA B, 252, GLY, O 2.40Å
A, 256, GLY, HA1 B, 253, ALA, O 2.77Å
A, 257, THR, HA B, 256, GLY, O 3.21Å