Leucine-rich repeat-containing protein 59

UniProt data

UniProt name: LRC59_HUMAN (Q96AG4)

Gene name: LRRC59; ORFNames=PRO1855

Organism: Homo sapiens (Human).

Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores. {ECO:0000269|PubMed:22321063}.

Subcellular location: Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Transmembrane domains:

  1. 245-265, 21 AA, Helical. {ECO:0000255}.

Sequence: 307 AA

10 20 30 40 50 60 MTKAGSKGGN LRDKLDGNEL DLSLSDLNEV PVKELAALPK ATILDLSCNK LTTLPSDFCG 70 80 90 100 110 120 LTHLVKLDLS KNKLQQLPAD FGRLVNLQHL DLLNNKLVTL PVSFAQLKNL KWLDLKDNPL 130 140 150 160 170 180 DPVLAKVAGD CLDEKQCKQC ANKVLQHMKA VQADQERERQ RRLEVEREAE KKREAKQRAK 190 200 210 220 230 240 EAQERELRKR EKAEEKERRR KEYDALKAAK REQEKKPKKE ANQAPKSKSG SRPRKPPPRK 250 260 270 280 290 300 HTRSWAVLKL LLLLLLFGVA GGLVACRVTE LQQQPLCTSV NTIYDNAVQG LRRHEILQWV LQTDSQQ

CATM prediction

The sequence of LRC59_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          250       260      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 TRSWAVLKLLLLLLLFGVAGGLVACRV 6.4 -50.9° 4.8 56.9 -24.2
Model 2 TRSWAVLKLLLLLLLFGVAGGLVACRV 7.2 -44.9° 0.1 45.2 -22.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 258, GLY, HA1 A, 255, LEU, O 3.19Å
B, 259, VAL, HA A, 258, GLY, O 2.44Å
B, 262, GLY, HA1 A, 259, VAL, O 3.03Å
A, 258, GLY, HA1 B, 255, LEU, O 3.19Å
A, 259, VAL, HA B, 258, GLY, O 2.44Å
A, 262, GLY, HA1 B, 259, VAL, O 3.03Å