Protein FAM162A

UniProt data

UniProt name: F162A_HUMAN (Q96A26)

Gene name: FAM162A; Synonyms=C3orf28, E2IG5; ORFNames=DC16, FWP001

Organism: Homo sapiens (Human).

Function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly. {ECO:0000269|PubMed:15082785}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}.

Transmembrane domains:

  1. 103-120, 18 AA, Helical. {ECO:0000255}.

Sequence: 154 AA

10 20 30 40 50 60 MGSLSGLRLA AGSCFRLCER DVSSSLRLTR SSDLKRINGF CTKPQESPGA PSRTYNRVPL 70 80 90 100 110 120 HKPTDWQKKI LIWSGRFKKE DEIPETVSLE MLDAAKNKMR VKISYLMIAL TVVGCIFMVI 130 140 150 EGKKAAQRHE TLTSLNLEKK ARLKEEAAMK AKTE

CATM prediction

The sequence of F162A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  100       110       120 
|    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 RVKISYLMIALTVVGCIFMVIEGK 7.1 -53.0° 2.0 44.9 -2.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 111, THR, HA A, 110, LEU, O 3.41Å
B, 114, GLY, HA1 A, 111, THR, O 3.02Å
A, 111, THR, HA B, 110, LEU, O 3.41Å
A, 114, GLY, HA1 B, 111, THR, O 3.02Å