Galactose-3-O-sulfotransferase 3

UniProt data

UniProt name: G3ST3_HUMAN (Q96A11)

Gene name: GAL3ST3

Organism: Homo sapiens (Human).

Function: Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha- 1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha- 1,4)GlcNAc. {ECO:0000269|PubMed:11323440, ECO:0000269|PubMed:11356829}.

Subcellular location: Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 20-40, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 431 AA

10 20 30 40 50 60 MPPILQRLQQ ATKMMSRRKI LLLVLGCSTV SLLIHQGAQL SWYPKLFPLS CPPLRNSPPR 70 80 90 100 110 120 PKHMTVAFLK THKTAGTTVQ NILFRFAERH NLTVALPHPS CEHQFCYPRN FSAHFVHPAT 130 140 150 160 170 180 RPPHVLASHL RFDRAELERL MPPSTVYVTI LREPAAMFES LFSYYNQYCP AFRRVPNASL 190 200 210 220 230 240 EAFLRAPEAY YRAGEHFAMF AHNTLAYDLG GDNERSPRDD AAYLAGLIRQ VEEVFSLVMI 250 260 270 280 290 300 AEYFDESLVL LRRLLAWDLD DVLYAKLNAR AASSRLAAIP AALARAARTW NALDAGLYDH 310 320 330 340 350 360 FNATFWRHVA RAGRACVERE ARELREARQR LLRRCFGDEP LLRPAAQIRT KQLQPWQPSR 370 380 390 400 410 420 KVDIMGYDLP GGGAGPATEA CLKLAMPEVQ YSNYLLRKQK RRGGARARPE PVLDNPPPRP 430 IRVLPRGPQG P

CATM prediction

The sequence of G3ST3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     20        30        40  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 RRKILLLVLGCSTVSLLIHQGAQLSWY 6.9 -55.0° 0.9 50.0 -7.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 37, GLY, HA1 A, 34, ILE, O 2.98Å
B, 38, ALA, HA A, 37, GLY, O 3.19Å
A, 37, GLY, HA1 B, 34, ILE, O 2.98Å
A, 38, ALA, HA B, 37, GLY, O 3.19Å